The challenge of a 2-year follow-up after intervention for weight loss in primary care
Background: Many weight loss programmes show short-term success, but long-term data in larger studies are scarce, especially in community settings. Attrition is common and complicates the interpretation of long-term outcomes. Objective: To investigate 2-year outcomes and explore issues of attrition...
Gespeichert in:
| Veröffentlicht in: | International Journal of Obesity 2014-06, Vol.38 (6), p.806-811 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 811 |
|---|---|
| container_issue | 6 |
| container_start_page | 806 |
| container_title | International Journal of Obesity |
| container_volume | 38 |
| creator | Holzapfel, C Cresswell, L Ahern, A L Fuller, N R Eberhard, M Stoll, J Mander, A P Jebb, S A Caterson, I D Hauner, H |
| description | Background:
Many weight loss programmes show short-term success, but long-term data in larger studies are scarce, especially in community settings. Attrition is common and complicates the interpretation of long-term outcomes.
Objective:
To investigate 2-year outcomes and explore issues of attrition and missing data.
Subjects:
A total of 772 overweight and obese adults recruited by primary care practices in Australia, Germany and the UK and randomised to a 12-month weight loss intervention delivered in a commercial programme (CP) or in standard care (SC).
Measurement:
Weight change from 0–24 and 12–24 months including measured weights only and measured and self-reported weights, using last observation carried forward (LOCF), baseline observation carried forward (BOCF), completers-only and missing-at-random (MAR) analyses.
Results:
A total of 203 participants completed the 24-month visit. Using measured weights only, there was a trend for greater 24-month weight loss in CP than in SC, but the difference was only statistically significant in the LOCF and BOCF analyses: LOCF: −4.14 vs −1.99 kg, difference adjusted for centre −2.08 kg,
P |
| doi_str_mv | 10.1038/ijo.2013.180 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4052429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A373254521</galeid><sourcerecordid>A373254521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c611t-d71885c24a076b85d579fd042b3a417896ad827102edf2f6119ba7330b89253c3</originalsourceid><addsrcrecordid>eNqFkt1rFDEUxQdR7Lb65rMERPHBWW--JpkXoZT6AQVfqq8hm0l2smQnazLT0v_ebHetu1KQQAI5v3tyuTlV9QrDHAOVH_0qzglgOscSnlQzzERTc9aKp9UMKIgaeMNPqtOcVwDAOZDn1QlhReJYzKqf171Fptch2GFpUXRII1LfWZ2QiyHE23raIO1Gm5Afyn5jh9HHoYgJ3Vq_7EcUYs5FRJvk1zrdIaOTfVE9czpk-3J_nlU_Pl9eX3ytr75_-XZxflWbBuOx7gSWkhvCNIhmIXnHRes6YGRBNcNCto3uJBEYiO0ccaWmXWhBKSxkSzg19Kz6tPPdTIu17UzpLumg9q2oqL06Vgbfq2W8UQw4YaQtBu_3Bin-mmwe1dpnY0PQg41TVriRwGhLCfwf5ZSJFjhjBX3zD7qKUxrKJO4pCrSRB9RSB6v84GJp0WxN1TkVlHDGCS7U_BGqrM6uvYmDdb7cHxW8OyjorQ5jn2OYtv-Wj8EPO9Ck8oXJuoe5YVDbbKmSLbXNlirZKvjrw1k_wH_CVIC3e0Bno4NLejA-_-Ukk5Tcc_WOy0UqqUsH03ns4d_djOGX</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534303684</pqid></control><display><type>article</type><title>The challenge of a 2-year follow-up after intervention for weight loss in primary care</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Holzapfel, C ; Cresswell, L ; Ahern, A L ; Fuller, N R ; Eberhard, M ; Stoll, J ; Mander, A P ; Jebb, S A ; Caterson, I D ; Hauner, H</creator><creatorcontrib>Holzapfel, C ; Cresswell, L ; Ahern, A L ; Fuller, N R ; Eberhard, M ; Stoll, J ; Mander, A P ; Jebb, S A ; Caterson, I D ; Hauner, H</creatorcontrib><description>Background:
Many weight loss programmes show short-term success, but long-term data in larger studies are scarce, especially in community settings. Attrition is common and complicates the interpretation of long-term outcomes.
Objective:
To investigate 2-year outcomes and explore issues of attrition and missing data.
Subjects:
A total of 772 overweight and obese adults recruited by primary care practices in Australia, Germany and the UK and randomised to a 12-month weight loss intervention delivered in a commercial programme (CP) or in standard care (SC).
Measurement:
Weight change from 0–24 and 12–24 months including measured weights only and measured and self-reported weights, using last observation carried forward (LOCF), baseline observation carried forward (BOCF), completers-only and missing-at-random (MAR) analyses.
Results:
A total of 203 participants completed the 24-month visit. Using measured weights only, there was a trend for greater 24-month weight loss in CP than in SC, but the difference was only statistically significant in the LOCF and BOCF analyses: LOCF: −4.14 vs −1.99 kg, difference adjusted for centre −2.08 kg,
P
<0.001; BOCF: −1.33 vs −0.74 kg, adjusted difference −0.60 kg,
P
=0.032; completers: −4.76 vs −2.99 kg, adjusted difference −1.53 kg,
P
=0.113; missing at random: −3.00 vs −1.94 kg, adjusted difference −1.04 kg,
P
=0.150. Both groups gained weight from 12–24 months and weight regain was significantly (
P
<0.001) greater for CP than for SC in all analysis approaches. Inclusion of self-reported weights from a further 138 participants did not change the interpretation of the findings.
Conclusion:
Initial weight loss was poorly maintained during the no-intervention follow-up, but both groups did have lower weight over the 24 months. Attrition was high in both groups, and assumptions about missing data had considerable impact on the magnitude and statistical significance of treatment effects. It is vital that trials on weight loss interventions consider the plausibility of these differences in an analytical approach when interpreting research findings and comparing data between studies.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2013.180</identifier><identifier>PMID: 24030517</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/700 ; 692/700/2817 ; Adult ; Australia - epidemiology ; Biological and medical sciences ; Data Collection ; Epidemiology ; Female ; Follow-Up Studies ; Germany - epidemiology ; Health Promotion and Disease Prevention ; Hospitals ; Humans ; Internal Medicine ; Intervention ; Lost to Follow-Up ; Male ; Medical practices ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Missing data ; Nutrition research ; Obesity ; Obesity - epidemiology ; Obesity - prevention & control ; Obesity - psychology ; Original ; original-article ; Patient compliance ; Patient Compliance - psychology ; Patient Compliance - statistics & numerical data ; Primary care ; Primary Health Care ; Public Health ; Self report ; Surveys ; Treatment Outcome ; United Kingdom - epidemiology ; Weight control ; Weight Gain ; Weight Loss ; Weight Reduction Programs</subject><ispartof>International Journal of Obesity, 2014-06, Vol.38 (6), p.806-811</ispartof><rights>The Author(s) 2014</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2014</rights><rights>Copyright © 2014 Macmillan Publishers Limited 2014 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-d71885c24a076b85d579fd042b3a417896ad827102edf2f6119ba7330b89253c3</citedby><cites>FETCH-LOGICAL-c611t-d71885c24a076b85d579fd042b3a417896ad827102edf2f6119ba7330b89253c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2013.180$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2013.180$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28483217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24030517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holzapfel, C</creatorcontrib><creatorcontrib>Cresswell, L</creatorcontrib><creatorcontrib>Ahern, A L</creatorcontrib><creatorcontrib>Fuller, N R</creatorcontrib><creatorcontrib>Eberhard, M</creatorcontrib><creatorcontrib>Stoll, J</creatorcontrib><creatorcontrib>Mander, A P</creatorcontrib><creatorcontrib>Jebb, S A</creatorcontrib><creatorcontrib>Caterson, I D</creatorcontrib><creatorcontrib>Hauner, H</creatorcontrib><title>The challenge of a 2-year follow-up after intervention for weight loss in primary care</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background:
Many weight loss programmes show short-term success, but long-term data in larger studies are scarce, especially in community settings. Attrition is common and complicates the interpretation of long-term outcomes.
Objective:
To investigate 2-year outcomes and explore issues of attrition and missing data.
Subjects:
A total of 772 overweight and obese adults recruited by primary care practices in Australia, Germany and the UK and randomised to a 12-month weight loss intervention delivered in a commercial programme (CP) or in standard care (SC).
Measurement:
Weight change from 0–24 and 12–24 months including measured weights only and measured and self-reported weights, using last observation carried forward (LOCF), baseline observation carried forward (BOCF), completers-only and missing-at-random (MAR) analyses.
Results:
A total of 203 participants completed the 24-month visit. Using measured weights only, there was a trend for greater 24-month weight loss in CP than in SC, but the difference was only statistically significant in the LOCF and BOCF analyses: LOCF: −4.14 vs −1.99 kg, difference adjusted for centre −2.08 kg,
P
<0.001; BOCF: −1.33 vs −0.74 kg, adjusted difference −0.60 kg,
P
=0.032; completers: −4.76 vs −2.99 kg, adjusted difference −1.53 kg,
P
=0.113; missing at random: −3.00 vs −1.94 kg, adjusted difference −1.04 kg,
P
=0.150. Both groups gained weight from 12–24 months and weight regain was significantly (
P
<0.001) greater for CP than for SC in all analysis approaches. Inclusion of self-reported weights from a further 138 participants did not change the interpretation of the findings.
Conclusion:
Initial weight loss was poorly maintained during the no-intervention follow-up, but both groups did have lower weight over the 24 months. Attrition was high in both groups, and assumptions about missing data had considerable impact on the magnitude and statistical significance of treatment effects. It is vital that trials on weight loss interventions consider the plausibility of these differences in an analytical approach when interpreting research findings and comparing data between studies.</description><subject>692/700</subject><subject>692/700/2817</subject><subject>Adult</subject><subject>Australia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Data Collection</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Germany - epidemiology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intervention</subject><subject>Lost to Follow-Up</subject><subject>Male</subject><subject>Medical practices</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Missing data</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - prevention & control</subject><subject>Obesity - psychology</subject><subject>Original</subject><subject>original-article</subject><subject>Patient compliance</subject><subject>Patient Compliance - psychology</subject><subject>Patient Compliance - statistics & numerical data</subject><subject>Primary care</subject><subject>Primary Health Care</subject><subject>Public Health</subject><subject>Self report</subject><subject>Surveys</subject><subject>Treatment Outcome</subject><subject>United Kingdom - epidemiology</subject><subject>Weight control</subject><subject>Weight Gain</subject><subject>Weight Loss</subject><subject>Weight Reduction Programs</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt1rFDEUxQdR7Lb65rMERPHBWW--JpkXoZT6AQVfqq8hm0l2smQnazLT0v_ebHetu1KQQAI5v3tyuTlV9QrDHAOVH_0qzglgOscSnlQzzERTc9aKp9UMKIgaeMNPqtOcVwDAOZDn1QlhReJYzKqf171Fptch2GFpUXRII1LfWZ2QiyHE23raIO1Gm5Afyn5jh9HHoYgJ3Vq_7EcUYs5FRJvk1zrdIaOTfVE9czpk-3J_nlU_Pl9eX3ytr75_-XZxflWbBuOx7gSWkhvCNIhmIXnHRes6YGRBNcNCto3uJBEYiO0ccaWmXWhBKSxkSzg19Kz6tPPdTIu17UzpLumg9q2oqL06Vgbfq2W8UQw4YaQtBu_3Bin-mmwe1dpnY0PQg41TVriRwGhLCfwf5ZSJFjhjBX3zD7qKUxrKJO4pCrSRB9RSB6v84GJp0WxN1TkVlHDGCS7U_BGqrM6uvYmDdb7cHxW8OyjorQ5jn2OYtv-Wj8EPO9Ck8oXJuoe5YVDbbKmSLbXNlirZKvjrw1k_wH_CVIC3e0Bno4NLejA-_-Ukk5Tcc_WOy0UqqUsH03ns4d_djOGX</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Holzapfel, C</creator><creator>Cresswell, L</creator><creator>Ahern, A L</creator><creator>Fuller, N R</creator><creator>Eberhard, M</creator><creator>Stoll, J</creator><creator>Mander, A P</creator><creator>Jebb, S A</creator><creator>Caterson, I D</creator><creator>Hauner, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140601</creationdate><title>The challenge of a 2-year follow-up after intervention for weight loss in primary care</title><author>Holzapfel, C ; Cresswell, L ; Ahern, A L ; Fuller, N R ; Eberhard, M ; Stoll, J ; Mander, A P ; Jebb, S A ; Caterson, I D ; Hauner, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-d71885c24a076b85d579fd042b3a417896ad827102edf2f6119ba7330b89253c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/700</topic><topic>692/700/2817</topic><topic>Adult</topic><topic>Australia - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Data Collection</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Germany - epidemiology</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intervention</topic><topic>Lost to Follow-Up</topic><topic>Male</topic><topic>Medical practices</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Missing data</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - prevention & control</topic><topic>Obesity - psychology</topic><topic>Original</topic><topic>original-article</topic><topic>Patient compliance</topic><topic>Patient Compliance - psychology</topic><topic>Patient Compliance - statistics & numerical data</topic><topic>Primary care</topic><topic>Primary Health Care</topic><topic>Public Health</topic><topic>Self report</topic><topic>Surveys</topic><topic>Treatment Outcome</topic><topic>United Kingdom - epidemiology</topic><topic>Weight control</topic><topic>Weight Gain</topic><topic>Weight Loss</topic><topic>Weight Reduction Programs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holzapfel, C</creatorcontrib><creatorcontrib>Cresswell, L</creatorcontrib><creatorcontrib>Ahern, A L</creatorcontrib><creatorcontrib>Fuller, N R</creatorcontrib><creatorcontrib>Eberhard, M</creatorcontrib><creatorcontrib>Stoll, J</creatorcontrib><creatorcontrib>Mander, A P</creatorcontrib><creatorcontrib>Jebb, S A</creatorcontrib><creatorcontrib>Caterson, I D</creatorcontrib><creatorcontrib>Hauner, H</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holzapfel, C</au><au>Cresswell, L</au><au>Ahern, A L</au><au>Fuller, N R</au><au>Eberhard, M</au><au>Stoll, J</au><au>Mander, A P</au><au>Jebb, S A</au><au>Caterson, I D</au><au>Hauner, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The challenge of a 2-year follow-up after intervention for weight loss in primary care</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>38</volume><issue>6</issue><spage>806</spage><epage>811</epage><pages>806-811</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Background:
Many weight loss programmes show short-term success, but long-term data in larger studies are scarce, especially in community settings. Attrition is common and complicates the interpretation of long-term outcomes.
Objective:
To investigate 2-year outcomes and explore issues of attrition and missing data.
Subjects:
A total of 772 overweight and obese adults recruited by primary care practices in Australia, Germany and the UK and randomised to a 12-month weight loss intervention delivered in a commercial programme (CP) or in standard care (SC).
Measurement:
Weight change from 0–24 and 12–24 months including measured weights only and measured and self-reported weights, using last observation carried forward (LOCF), baseline observation carried forward (BOCF), completers-only and missing-at-random (MAR) analyses.
Results:
A total of 203 participants completed the 24-month visit. Using measured weights only, there was a trend for greater 24-month weight loss in CP than in SC, but the difference was only statistically significant in the LOCF and BOCF analyses: LOCF: −4.14 vs −1.99 kg, difference adjusted for centre −2.08 kg,
P
<0.001; BOCF: −1.33 vs −0.74 kg, adjusted difference −0.60 kg,
P
=0.032; completers: −4.76 vs −2.99 kg, adjusted difference −1.53 kg,
P
=0.113; missing at random: −3.00 vs −1.94 kg, adjusted difference −1.04 kg,
P
=0.150. Both groups gained weight from 12–24 months and weight regain was significantly (
P
<0.001) greater for CP than for SC in all analysis approaches. Inclusion of self-reported weights from a further 138 participants did not change the interpretation of the findings.
Conclusion:
Initial weight loss was poorly maintained during the no-intervention follow-up, but both groups did have lower weight over the 24 months. Attrition was high in both groups, and assumptions about missing data had considerable impact on the magnitude and statistical significance of treatment effects. It is vital that trials on weight loss interventions consider the plausibility of these differences in an analytical approach when interpreting research findings and comparing data between studies.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24030517</pmid><doi>10.1038/ijo.2013.180</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2014-06, Vol.38 (6), p.806-811 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4052429 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 692/700 692/700/2817 Adult Australia - epidemiology Biological and medical sciences Data Collection Epidemiology Female Follow-Up Studies Germany - epidemiology Health Promotion and Disease Prevention Hospitals Humans Internal Medicine Intervention Lost to Follow-Up Male Medical practices Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Missing data Nutrition research Obesity Obesity - epidemiology Obesity - prevention & control Obesity - psychology Original original-article Patient compliance Patient Compliance - psychology Patient Compliance - statistics & numerical data Primary care Primary Health Care Public Health Self report Surveys Treatment Outcome United Kingdom - epidemiology Weight control Weight Gain Weight Loss Weight Reduction Programs |
| title | The challenge of a 2-year follow-up after intervention for weight loss in primary care |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T21%3A57%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20challenge%20of%20a%202-year%20follow-up%20after%20intervention%20for%20weight%20loss%20in%20primary%20care&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Holzapfel,%20C&rft.date=2014-06-01&rft.volume=38&rft.issue=6&rft.spage=806&rft.epage=811&rft.pages=806-811&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/ijo.2013.180&rft_dat=%3Cgale_pubme%3EA373254521%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1534303684&rft_id=info:pmid/24030517&rft_galeid=A373254521&rfr_iscdi=true |