Pharmacological Treatments in Gambling Disorder : A Qualitative Review
Gambling disorder (GD) is a psychiatric condition associated with both social and family costs; DSM-5 currently includes GD among addictive disorders. Despite the high burden of this condition, to date there are no treatment guidelines approved by Food and Drug Administration (FDA). Purpose of this...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-7 |
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| creator | Lupi, Matteo Martinotti, Giovanni Acciavatti, Tiziano Pettorruso, Mauro Brunetti, Marcella Santacroce, Rita Cinosi, Eduardo Di Iorio, Giuseppe Di Nicola, Marco di Giannantonio, Massimo |
| description | Gambling disorder (GD) is a psychiatric condition associated with both social and family costs; DSM-5 currently includes GD among addictive disorders. Despite the high burden of this condition, to date there are no treatment guidelines approved by Food and Drug Administration (FDA). Purpose of this paper is to offer a qualitative overview about the different pharmacologic agents used for the treatment of GD. Our analysis, conducted on a final selection of 75 scientific papers, demonstrates that a variety of pharmaceutical classes have been utilised, with different results. Published data, although limited by brief duration of the studies and small number of enrolled subjects, shows mixed evidence for serotonergic antidepressants, opioid antagonists, and mood stabilizers. Other compounds, such as glutamatergic agents and psychostimulants, deserve further studies. |
| doi_str_mv | 10.1155/2014/537306 |
| format | Article |
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Despite the high burden of this condition, to date there are no treatment guidelines approved by Food and Drug Administration (FDA). Purpose of this paper is to offer a qualitative overview about the different pharmacologic agents used for the treatment of GD. Our analysis, conducted on a final selection of 75 scientific papers, demonstrates that a variety of pharmaceutical classes have been utilised, with different results. Published data, although limited by brief duration of the studies and small number of enrolled subjects, shows mixed evidence for serotonergic antidepressants, opioid antagonists, and mood stabilizers. Other compounds, such as glutamatergic agents and psychostimulants, deserve further studies.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/537306</identifier><identifier>PMID: 24955359</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Addictions ; Addictive behaviors ; Antipsychotic Agents - therapeutic use ; Behavior ; Behavior, Addictive - drug therapy ; Behavior, Addictive - physiopathology ; Bipolar disorder ; Clinical trials ; Comorbidity ; Compulsive gambling ; Drug dosages ; Drug therapy ; Excitatory Amino Acid Agents - therapeutic use ; Gambling ; Gambling - drug therapy ; Gambling - pathology ; Humans ; Psychiatric research ; Psychopharmacology ; Review ; Studies ; United States ; United States Food and Drug Administration</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Matteo Lupi et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Matteo Lupi et al. Matteo Lupi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Matteo Lupi et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-ca168351905b73ae932bb0bb86db09b438739e5103470820f45a565e357729833</citedby><cites>FETCH-LOGICAL-c593t-ca168351905b73ae932bb0bb86db09b438739e5103470820f45a565e357729833</cites><orcidid>0000-0003-1377-9183 ; 0000-0002-4164-3040</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052082/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052082/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24955359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Corazza, Ornella</contributor><creatorcontrib>Lupi, Matteo</creatorcontrib><creatorcontrib>Martinotti, Giovanni</creatorcontrib><creatorcontrib>Acciavatti, Tiziano</creatorcontrib><creatorcontrib>Pettorruso, Mauro</creatorcontrib><creatorcontrib>Brunetti, Marcella</creatorcontrib><creatorcontrib>Santacroce, Rita</creatorcontrib><creatorcontrib>Cinosi, Eduardo</creatorcontrib><creatorcontrib>Di Iorio, Giuseppe</creatorcontrib><creatorcontrib>Di Nicola, Marco</creatorcontrib><creatorcontrib>di Giannantonio, Massimo</creatorcontrib><title>Pharmacological Treatments in Gambling Disorder : A Qualitative Review</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Gambling disorder (GD) is a psychiatric condition associated with both social and family costs; DSM-5 currently includes GD among addictive disorders. Despite the high burden of this condition, to date there are no treatment guidelines approved by Food and Drug Administration (FDA). Purpose of this paper is to offer a qualitative overview about the different pharmacologic agents used for the treatment of GD. Our analysis, conducted on a final selection of 75 scientific papers, demonstrates that a variety of pharmaceutical classes have been utilised, with different results. Published data, although limited by brief duration of the studies and small number of enrolled subjects, shows mixed evidence for serotonergic antidepressants, opioid antagonists, and mood stabilizers. Other compounds, such as glutamatergic agents and psychostimulants, deserve further studies.</description><subject>Addictions</subject><subject>Addictive behaviors</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Behavior</subject><subject>Behavior, Addictive - drug therapy</subject><subject>Behavior, Addictive - physiopathology</subject><subject>Bipolar disorder</subject><subject>Clinical trials</subject><subject>Comorbidity</subject><subject>Compulsive gambling</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Excitatory Amino Acid Agents - therapeutic use</subject><subject>Gambling</subject><subject>Gambling - drug therapy</subject><subject>Gambling - pathology</subject><subject>Humans</subject><subject>Psychiatric research</subject><subject>Psychopharmacology</subject><subject>Review</subject><subject>Studies</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1rFDEYh4MottSePCsDXqRl23y9ycSDsNS2Fgp-UM8hmc3spmQmNZnZ0v_eDFPXj4vmkkAeHn7v-0PoJcEnhACcUkz4KTDJsHiC9ikjfCEIJ093b8b20GHOt7icmgisxHO0R7kCYKD20cXnjUmdaWKIa9-YUN0kZ4bO9UOufF9dms4G36-rDz7HtHKpelctqy-jCX4wg9-66qvbenf_Aj1rTcju8PE-QN8uzm_OPi6uP11enS2vFw0oNiwaQ0TNgCgMVjLjFKPWYmtrsbJYWc5qyZQDghmXuKa45WBAgGMgJVU1Ywfo_ey9G23nVk3JmUzQd8l3Jj3oaLz-86f3G72OW80x0GIsgrePghS_jy4PuvO5cSGY3sUxawJC1KCAwn-gJSiRNUyx3vyF3sYx9WUTheJSEQFS_KLWJjjt-zaWiM0k1UtOJaZl6inh8Uw1KeacXLubjmA9da6nzvXceaFf_76QHfuz4QIczcDG9ytz7_9hezXDriCuNTu4zCBKvh-Ez7i-</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Lupi, Matteo</creator><creator>Martinotti, Giovanni</creator><creator>Acciavatti, Tiziano</creator><creator>Pettorruso, Mauro</creator><creator>Brunetti, Marcella</creator><creator>Santacroce, Rita</creator><creator>Cinosi, Eduardo</creator><creator>Di Iorio, Giuseppe</creator><creator>Di Nicola, Marco</creator><creator>di Giannantonio, Massimo</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1377-9183</orcidid><orcidid>https://orcid.org/0000-0002-4164-3040</orcidid></search><sort><creationdate>20140101</creationdate><title>Pharmacological Treatments in Gambling Disorder : A Qualitative Review</title><author>Lupi, Matteo ; Martinotti, Giovanni ; Acciavatti, Tiziano ; Pettorruso, Mauro ; Brunetti, Marcella ; Santacroce, Rita ; Cinosi, Eduardo ; Di Iorio, Giuseppe ; Di Nicola, Marco ; di Giannantonio, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-ca168351905b73ae932bb0bb86db09b438739e5103470820f45a565e357729833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Addictions</topic><topic>Addictive behaviors</topic><topic>Antipsychotic Agents - 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Despite the high burden of this condition, to date there are no treatment guidelines approved by Food and Drug Administration (FDA). Purpose of this paper is to offer a qualitative overview about the different pharmacologic agents used for the treatment of GD. Our analysis, conducted on a final selection of 75 scientific papers, demonstrates that a variety of pharmaceutical classes have been utilised, with different results. Published data, although limited by brief duration of the studies and small number of enrolled subjects, shows mixed evidence for serotonergic antidepressants, opioid antagonists, and mood stabilizers. 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| subjects | Addictions Addictive behaviors Antipsychotic Agents - therapeutic use Behavior Behavior, Addictive - drug therapy Behavior, Addictive - physiopathology Bipolar disorder Clinical trials Comorbidity Compulsive gambling Drug dosages Drug therapy Excitatory Amino Acid Agents - therapeutic use Gambling Gambling - drug therapy Gambling - pathology Humans Psychiatric research Psychopharmacology Review Studies United States United States Food and Drug Administration |
| title | Pharmacological Treatments in Gambling Disorder : A Qualitative Review |
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