Biophysical Mechanism of the Protective Effect of Blue Honeysuckle (Lonicera caerulea L. var. kamtschatica Sevast.) Polyphenols Extracts Against Lipid Peroxidation of Erythrocyte and Lipid Membranes
The aim of the present research was to determine the effect of blue honeysuckle fruit and leaf extracts components on the physical properties of erythrocyte and lipid membranes and assess their antioxidant properties. The HPLC analysis showed that the extracts are rich in polyphenol anthocyanins in...
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| Veröffentlicht in: | The Journal of membrane biology 2014-07, Vol.247 (7), p.611-625 |
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| creator | Bonarska-Kujawa, D. Pruchnik, H. Cyboran, S. Żyłka, R. Oszmiański, J. Kleszczyńska, H. |
| description | The aim of the present research was to determine the effect of blue honeysuckle fruit and leaf extracts components on the physical properties of erythrocyte and lipid membranes and assess their antioxidant properties. The HPLC analysis showed that the extracts are rich in polyphenol anthocyanins in fruits and flavonoids in leaves. The results indicate that both extracts have antioxidant activity and protect the red blood cell membrane against oxidation induced by UVC irradiation and AAPH. The extracts do not induce hemolysis and slightly increase osmotic resistance of erythrocytes. The research showed that extracts components are incorporated mainly in the external part of the erythrocyte membrane, inducing the formation of echinocytes. The values of generalized polarization and fluorescence anisotropy indicate that the extracts polyphenols alter the packing arrangement of the hydrophilic part of the erythrocyte and lipid membranes, without changing the fluidity of the hydrophobic part. The DSC results also show that the extract components do not change the main phase transition temperature of DPPC membrane. Studies of electric parameters of membranes modified by the extracts showed that they slightly stabilize lipid membranes and do not reduce their specific resistance or capacity. Examination of IR spectra indicates small changes in the degree of hydration in the hydrophilic region of liposomes under the action of the extracts. The location of polyphenolic compounds in the hydrophilic part of the membrane seems to constitute a protective shield of the cell against other substances, the reactive forms of oxygen in particular. |
| doi_str_mv | 10.1007/s00232-014-9677-5 |
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Polyphenols Extracts Against Lipid Peroxidation of Erythrocyte and Lipid Membranes</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Bonarska-Kujawa, D. ; Pruchnik, H. ; Cyboran, S. ; Żyłka, R. ; Oszmiański, J. ; Kleszczyńska, H.</creator><creatorcontrib>Bonarska-Kujawa, D. ; Pruchnik, H. ; Cyboran, S. ; Żyłka, R. ; Oszmiański, J. ; Kleszczyńska, H.</creatorcontrib><description>The aim of the present research was to determine the effect of blue honeysuckle fruit and leaf extracts components on the physical properties of erythrocyte and lipid membranes and assess their antioxidant properties. The HPLC analysis showed that the extracts are rich in polyphenol anthocyanins in fruits and flavonoids in leaves. The results indicate that both extracts have antioxidant activity and protect the red blood cell membrane against oxidation induced by UVC irradiation and AAPH. The extracts do not induce hemolysis and slightly increase osmotic resistance of erythrocytes. The research showed that extracts components are incorporated mainly in the external part of the erythrocyte membrane, inducing the formation of echinocytes. The values of generalized polarization and fluorescence anisotropy indicate that the extracts polyphenols alter the packing arrangement of the hydrophilic part of the erythrocyte and lipid membranes, without changing the fluidity of the hydrophobic part. The DSC results also show that the extract components do not change the main phase transition temperature of DPPC membrane. Studies of electric parameters of membranes modified by the extracts showed that they slightly stabilize lipid membranes and do not reduce their specific resistance or capacity. Examination of IR spectra indicates small changes in the degree of hydration in the hydrophilic region of liposomes under the action of the extracts. The location of polyphenolic compounds in the hydrophilic part of the membrane seems to constitute a protective shield of the cell against other substances, the reactive forms of oxygen in particular.</description><identifier>ISSN: 0022-2631</identifier><identifier>EISSN: 1432-1424</identifier><identifier>DOI: 10.1007/s00232-014-9677-5</identifier><identifier>PMID: 24862869</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Cell Shape - drug effects ; Erythrocyte Membrane - chemistry ; Erythrocyte Membrane - drug effects ; Erythrocyte Membrane - metabolism ; Erythrocytes ; Erythrocytes - drug effects ; Erythrocytes - metabolism ; Erythrocytes - ultrastructure ; Hemolysis - drug effects ; Human Physiology ; Life Sciences ; Lipid Peroxidation - drug effects ; Lipids ; Lonicera - chemistry ; Membrane Fluidity - drug effects ; Membranes ; Osmotic Pressure - drug effects ; Phase Transition ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - chemistry ; Polyphenols - pharmacology ; Surface-Active Agents - chemistry ; Surface-Active Agents - pharmacology ; Swine ; Temperature</subject><ispartof>The Journal of membrane biology, 2014-07, Vol.247 (7), p.611-625</ispartof><rights>The Author(s) 2014</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-6e3acc9022e50911d129f0b58c558415bb1a89ab693f6d8c476cdaef8f4ccb4d3</citedby><cites>FETCH-LOGICAL-c503t-6e3acc9022e50911d129f0b58c558415bb1a89ab693f6d8c476cdaef8f4ccb4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00232-014-9677-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00232-014-9677-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24862869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonarska-Kujawa, D.</creatorcontrib><creatorcontrib>Pruchnik, H.</creatorcontrib><creatorcontrib>Cyboran, S.</creatorcontrib><creatorcontrib>Żyłka, R.</creatorcontrib><creatorcontrib>Oszmiański, J.</creatorcontrib><creatorcontrib>Kleszczyńska, H.</creatorcontrib><title>Biophysical Mechanism of the Protective Effect of Blue Honeysuckle (Lonicera caerulea L. var. kamtschatica Sevast.) Polyphenols Extracts Against Lipid Peroxidation of Erythrocyte and Lipid Membranes</title><title>The Journal of membrane biology</title><addtitle>J Membrane Biol</addtitle><addtitle>J Membr Biol</addtitle><description>The aim of the present research was to determine the effect of blue honeysuckle fruit and leaf extracts components on the physical properties of erythrocyte and lipid membranes and assess their antioxidant properties. The HPLC analysis showed that the extracts are rich in polyphenol anthocyanins in fruits and flavonoids in leaves. The results indicate that both extracts have antioxidant activity and protect the red blood cell membrane against oxidation induced by UVC irradiation and AAPH. The extracts do not induce hemolysis and slightly increase osmotic resistance of erythrocytes. The research showed that extracts components are incorporated mainly in the external part of the erythrocyte membrane, inducing the formation of echinocytes. The values of generalized polarization and fluorescence anisotropy indicate that the extracts polyphenols alter the packing arrangement of the hydrophilic part of the erythrocyte and lipid membranes, without changing the fluidity of the hydrophobic part. The DSC results also show that the extract components do not change the main phase transition temperature of DPPC membrane. Studies of electric parameters of membranes modified by the extracts showed that they slightly stabilize lipid membranes and do not reduce their specific resistance or capacity. Examination of IR spectra indicates small changes in the degree of hydration in the hydrophilic region of liposomes under the action of the extracts. The location of polyphenolic compounds in the hydrophilic part of the membrane seems to constitute a protective shield of the cell against other substances, the reactive forms of oxygen in particular.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Shape - drug effects</subject><subject>Erythrocyte Membrane - chemistry</subject><subject>Erythrocyte Membrane - drug effects</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocytes</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - metabolism</subject><subject>Erythrocytes - ultrastructure</subject><subject>Hemolysis - drug effects</subject><subject>Human Physiology</subject><subject>Life Sciences</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Lonicera - chemistry</subject><subject>Membrane Fluidity - drug effects</subject><subject>Membranes</subject><subject>Osmotic Pressure - drug effects</subject><subject>Phase Transition</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Polyphenols - chemistry</subject><subject>Polyphenols - pharmacology</subject><subject>Surface-Active Agents - chemistry</subject><subject>Surface-Active Agents - pharmacology</subject><subject>Swine</subject><subject>Temperature</subject><issn>0022-2631</issn><issn>1432-1424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ks1u1DAUhSMEokPhAdggS2zKIoOdOH8bpLYaKFIqRgLWluPcTNw6dmo7o-YF-1x1NENVkFjZ8vnuufdaJ4reE7wmGBefHcZJmsSY0LjKiyLOXkQrQsMLoQl9Ga2CnMRJnpKT6I1zNxiTosjp6-gkoWWelHm1ih4upBn72UnBFboG0XMt3YBMh3wPaGuNB-HlHtCm68JtES7UBOjKaJjdJG4VoLPaaCnAciQ42EkBR_Ua7bldo1s-eBdMffBHP2HPnV9_Qluj5rEHbZRDm3tvufAOne-41M6jWo6yRVuw5l62odDopenGzr63RsweENftkbqGobFcg3sbveq4cvDueJ5Gv79ufl1exfWPb98vz-tYZDj1cQ4pF6IK3wIZrghpSVJ1uMlKkWUlJVnTEF5WvMmrtMvbUtAiFy2HruyoEA1t09Poy8F3nJoBWgE6TK_YaOXA7cwMl-xvRcue7cyeUZwlmGTB4OxoYM3dBM6zQToBSoUtzORYQAKYVyQN6Md_0BszWR3WWyhKaYXLKlDkQAlrnLPQPQ1DMFtSwg4pYSElbEkJW4b48HyLp4o_sQhAcgBckPQO7LPW_3V9BGKTzHM</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Bonarska-Kujawa, D.</creator><creator>Pruchnik, H.</creator><creator>Cyboran, S.</creator><creator>Żyłka, R.</creator><creator>Oszmiański, J.</creator><creator>Kleszczyńska, H.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140701</creationdate><title>Biophysical Mechanism of the Protective Effect of Blue Honeysuckle (Lonicera caerulea L. var. kamtschatica Sevast.) Polyphenols Extracts Against Lipid Peroxidation of Erythrocyte and Lipid Membranes</title><author>Bonarska-Kujawa, D. ; Pruchnik, H. ; Cyboran, S. ; Żyłka, R. ; Oszmiański, J. ; Kleszczyńska, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-6e3acc9022e50911d129f0b58c558415bb1a89ab693f6d8c476cdaef8f4ccb4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Shape - drug effects</topic><topic>Erythrocyte Membrane - chemistry</topic><topic>Erythrocyte Membrane - drug effects</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocytes</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - metabolism</topic><topic>Erythrocytes - ultrastructure</topic><topic>Hemolysis - drug effects</topic><topic>Human Physiology</topic><topic>Life Sciences</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Lonicera - chemistry</topic><topic>Membrane Fluidity - drug effects</topic><topic>Membranes</topic><topic>Osmotic Pressure - drug effects</topic><topic>Phase Transition</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyphenols</topic><topic>Polyphenols - chemistry</topic><topic>Polyphenols - pharmacology</topic><topic>Surface-Active Agents - chemistry</topic><topic>Surface-Active Agents - pharmacology</topic><topic>Swine</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonarska-Kujawa, D.</creatorcontrib><creatorcontrib>Pruchnik, H.</creatorcontrib><creatorcontrib>Cyboran, S.</creatorcontrib><creatorcontrib>Żyłka, R.</creatorcontrib><creatorcontrib>Oszmiański, J.</creatorcontrib><creatorcontrib>Kleszczyńska, H.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of membrane biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonarska-Kujawa, D.</au><au>Pruchnik, H.</au><au>Cyboran, S.</au><au>Żyłka, R.</au><au>Oszmiański, J.</au><au>Kleszczyńska, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biophysical Mechanism of the Protective Effect of Blue Honeysuckle (Lonicera caerulea L. var. kamtschatica Sevast.) Polyphenols Extracts Against Lipid Peroxidation of Erythrocyte and Lipid Membranes</atitle><jtitle>The Journal of membrane biology</jtitle><stitle>J Membrane Biol</stitle><addtitle>J Membr Biol</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>247</volume><issue>7</issue><spage>611</spage><epage>625</epage><pages>611-625</pages><issn>0022-2631</issn><eissn>1432-1424</eissn><abstract>The aim of the present research was to determine the effect of blue honeysuckle fruit and leaf extracts components on the physical properties of erythrocyte and lipid membranes and assess their antioxidant properties. The HPLC analysis showed that the extracts are rich in polyphenol anthocyanins in fruits and flavonoids in leaves. The results indicate that both extracts have antioxidant activity and protect the red blood cell membrane against oxidation induced by UVC irradiation and AAPH. The extracts do not induce hemolysis and slightly increase osmotic resistance of erythrocytes. The research showed that extracts components are incorporated mainly in the external part of the erythrocyte membrane, inducing the formation of echinocytes. The values of generalized polarization and fluorescence anisotropy indicate that the extracts polyphenols alter the packing arrangement of the hydrophilic part of the erythrocyte and lipid membranes, without changing the fluidity of the hydrophobic part. The DSC results also show that the extract components do not change the main phase transition temperature of DPPC membrane. Studies of electric parameters of membranes modified by the extracts showed that they slightly stabilize lipid membranes and do not reduce their specific resistance or capacity. Examination of IR spectra indicates small changes in the degree of hydration in the hydrophilic region of liposomes under the action of the extracts. The location of polyphenolic compounds in the hydrophilic part of the membrane seems to constitute a protective shield of the cell against other substances, the reactive forms of oxygen in particular.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>24862869</pmid><doi>10.1007/s00232-014-9677-5</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of membrane biology, 2014-07, Vol.247 (7), p.611-625 |
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| subjects | Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Biochemistry Biomedical and Life Sciences Cell Shape - drug effects Erythrocyte Membrane - chemistry Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - ultrastructure Hemolysis - drug effects Human Physiology Life Sciences Lipid Peroxidation - drug effects Lipids Lonicera - chemistry Membrane Fluidity - drug effects Membranes Osmotic Pressure - drug effects Phase Transition Plant Extracts - chemistry Plant Extracts - pharmacology Polyphenols Polyphenols - chemistry Polyphenols - pharmacology Surface-Active Agents - chemistry Surface-Active Agents - pharmacology Swine Temperature |
| title | Biophysical Mechanism of the Protective Effect of Blue Honeysuckle (Lonicera caerulea L. var. kamtschatica Sevast.) Polyphenols Extracts Against Lipid Peroxidation of Erythrocyte and Lipid Membranes |
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