Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE

Current multiple sclerosis (MS) therapies only partially prevent chronically worsening neurological deficits, which are largely attributable to progressive loss of CNS axons. Prior studies of experimental autoimmune encephalomyelitis (EAE) induced in C57BL/6 mice by immunization with myelin oligoden...

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Veröffentlicht in:	The Journal of neuroscience 2014-06, Vol.34 (24), p.8175-8185
Hauptverfasser:	Moreno, Monica, Bannerman, Peter, Ma, Joyce, Guo, Fuzheng, Miers, Laird, Soulika, Athena M, Pleasure, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Astrocytes - metabolism Axons - pathology Axons - ultrastructure Bacterial Proteins - genetics Central Nervous System - pathology Central Nervous System - ultrastructure Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Flow Cytometry Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Luminescent Proteins - genetics Macrophages - immunology Macrophages - metabolism Macrophages - ultrastructure Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission Myelin-Oligodendrocyte Glycoprotein - toxicity Peptide Fragments - toxicity Proteins - genetics
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