Role of the Na~+/K~+/2Cl~- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

AIM:To investigate the role of Na+/K+/2Cl-cotransporter 1(NKCC1)in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell carcinoma(ESCC).METHODS:An immunohistochemical analysis was performed on 68 primary tum...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2014-06, Vol.20 (22), p.6844-6859
Hauptverfasser:	Shiozaki, Atsushi, Nako, Yoshito, Ichikawa, Daisuke, Konishi, Hirotaka, Komatsu, Shuhei, Kubota, Takeshi, Fujiwara, Hitoshi, Okamoto, Kazuma, Kishimoto, Mitsuo, Marunaka, Yoshinori, Otsuji, Eigo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation Cell Line, Tumor Cell Proliferation Esophageal Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Female G2 Phase Cell Cycle Checkpoints - drug effects Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans Immunohistochemistry Male Middle Aged Na+/K+/2Cl-cotransporter Oligonucleotide Array Sequence Analysis Original RNA Interference Signal Transduction Sodium Potassium Chloride Symporter Inhibitors - pharmacology Solute Carrier Family 12, Member 2 - drug effects Solute Carrier Family 12, Member 2 - genetics Solute Carrier Family 12, Member 2 - metabolism Transfection
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