A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties

NAF‐1 is an important [2Fe–2S] NEET protein associated with human health and disease. A mis‐splicing mutation in NAF‐1 results in Wolfram Syndrome type 2, a lethal childhood disease. Upregulation of NAF‐1 is found in epithelial breast cancer cells, and suppression of NAF‐1 expression by knockdown si...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2014-06, Vol.70 (6), p.1572-1578
Hauptverfasser:	Tamir, Sagi, Eisenberg-Domovich, Yael, Conlan, Andrea R., Stofleth, Jason T., Lipper, Colin H., Paddock, Mark L., Mittler, Ron, Jennings, Patricia A., Livnah, Oded, Nechushtai, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	2Fe-2S cluster transfer and cluster stability 60 APPLIED LIFE SCIENCES autophagy Binding Breast breast cancer Clusters CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY Crystallography, X-Ray CRYSTALS Electrode potentials IN VIVO INHIBITION Iron-Sulfur Proteins - chemistry Iron-Sulfur Proteins - genetics Iron-Sulfur Proteins - metabolism LIGANDS longevity Mutations Native Polyacrylamide Gel Electrophoresis NEOPLASMS Point Mutation PROTEINS R FACTORS redox potential Research Papers RESOLUTION Spectrophotometry, Ultraviolet Surgical implants TRANSFER FUNCTIONS TUNGSTEN WFS2
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