Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer's disease. The mechanism by which TREM2 influences the susceptibility to Alzheimer's disease is currently unknown. TREM2 is expressed by microglia and is thought to regu...

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Veröffentlicht in:	Molecular neurodegeneration 2014-06, Vol.9 (1), p.20-20, Article 20
Hauptverfasser:	Ulrich, Jason D, Finn, Mary Beth, Wang, Yaming, Shen, Alice, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Piccio, Laura, Colonna, Marco, Holtzman, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Protein Precursor - genetics Animals Disease Models, Animal Female Heterozygote Male Membrane Glycoproteins - genetics Mice Mice, Transgenic Microglia - metabolism Microglia - pathology Plaque, Amyloid - genetics Plaque, Amyloid - pathology Presenilin-1 - genetics Real-Time Polymerase Chain Reaction Receptors, Immunologic - genetics
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