Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase

PLC-isozymes are central elements of cellular signaling downstream of numerous receptors. PLCγ2 is a pivotal component of B cell receptor (BCR) signaling. The regulation of PLCγ2-dependent signaling functions by Tyr-phosphorylation is well characterized, however, the potential role of Ser/Thr phosph...

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Veröffentlicht in:	Cellular signalling 2012-11, Vol.24 (11), p.2070-2075
Hauptverfasser:	Deason-Towne, Francina, Perraud, Anne-Laure, Schmitz, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals B Cell Receptor signaling Calcium - metabolism Cell Line Chickens Humans Hypomagnesia Magnesium - metabolism Molecular Sequence Data Phospholipase C gamma - chemistry Phospholipase C gamma - metabolism Phosphorylation PLCγ2 Protein-Serine-Threonine Kinases Receptors, Antigen, B-Cell - metabolism Ser Serine - metabolism Signal Transduction Thr phosphorylation TRPM7 Threonine - metabolism TRPM Cation Channels - metabolism
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