Cross-Electrophile Coupling: Principles of Reactivity and Selectivity
A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this...
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| Veröffentlicht in: | Journal of organic chemistry 2014-06, Vol.79 (11), p.4793-4798 |
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| container_end_page | 4798 |
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| container_title | Journal of organic chemistry |
| container_volume | 79 |
| creator | Everson, Daniel A Weix, Daniel J |
| description | A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this challenge: (1) employing an excess of one reagent; (2) electronic differentiation of starting materials; (3) catalyst–substrate steric matching; and (4) radical chain processes. Each method is described using examples from the recent literature. |
| doi_str_mv | 10.1021/jo500507s |
| format | Article |
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| ispartof | Journal of organic chemistry, 2014-06, Vol.79 (11), p.4793-4798 |
| issn | 0022-3263 1520-6904 1520-6904 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Benzyl Compounds - chemistry Catalysis catalysts chemical reactions Cross-Linking Reagents - chemistry electrons Indicators and Reagents - chemistry JOC Lewis acids Molecular Structure organic chemistry Oxidation-Reduction synthesis |
| title | Cross-Electrophile Coupling: Principles of Reactivity and Selectivity |
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