A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy as they contain many relevant immunogenic epitopes to help prevent tumor escape. Two common methods of tumor lysate preparations are freeze-thaw processing and UVB irradiation to induce necrosis and apoptosis, respecti...

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Veröffentlicht in:	Clinical cancer research 2013-09, Vol.19 (17), p.4801-4815
Hauptverfasser:	CHIANG, Cheryl Lai-Lai, KANDALAFT, Lana E, LEVINE, Bruce L, KALOS, Michael, CZERNIECKI, Brian J, TORIGIAN, Drew A, POWELL, Daniel J, MICK, Rosemarie, COUKOS, George, TANYI, Janos, HAGEMANN, Andrea R, MOTZ, Gregory T, SVORONOS, Nikolaos, MONTONE, Kathleen, MANTIA-SMALDONE, Gina M, SMITH, Lori, NISENBAUM, Harvey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - immunology Antigens, Neoplasm - administration & dosage Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Dendritic Cells - chemistry Dendritic Cells - immunology Disease-Free Survival Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Hypochlorous Acid - pharmacology Immunotherapy Interleukin-10 - blood Lymphocyte Culture Test, Mixed Medical sciences Mice Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Ovarian Neoplasms - chemistry Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - therapy Oxidation-Reduction Pharmacology. Drug treatments T-Lymphocytes, Regulatory - immunology Tumors
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