Topoisomerase IV is a Target of Quinolones in Escherichia coli

We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition of topo IV becomes apparent only when gyrase is mutated to quinolone resistance. In such mutants, these antibiotics caused accumulation of replication catenanes, which is...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-12, Vol.92 (25), p.11801-11805
Hauptverfasser:	Khodursky, Arkady B., Zechiedrich, E. Lynn, Cozzarelli, Nicholas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Anti-Bacterial Agents - pharmacology Antibacterials Bacteria Biochemistry Catenanes Ciprofloxacin DNA DNA Gyrase DNA replication DNA Replication - drug effects DNA Topoisomerase IV DNA Topoisomerases, Type II - drug effects DNA Topoisomerases, Type II - genetics DNA, Bacterial - metabolism Dose-Response Relationship, Drug Drug Resistance, Microbial Enzymes Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Genetic mutation Mutation Norfloxacin - pharmacology Nucleic Acid Conformation Plasmids Poisons Quinolones Quinolones - pharmacology
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