Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair

Skin-resident T cells have been shown to play important roles in tissue homeostasis and wound repair, but their role in UV radiation (UVR)-mediated skin injury and subsequent tissue regeneration is less clear. In this study, we demonstrate that acute UVR rapidly activates skin-resident T cells in hu...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-06, Vol.192 (12), p.5695-5702
Hauptverfasser:	MacLeod, Amanda S, Rudolph, Ross, Corriden, Ross, Ye, Ivan, Garijo, Olivia, Havran, Wendy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - immunology DNA Repair - genetics DNA Repair - immunology DNA Repair - radiation effects Epidermis - immunology Epidermis - pathology Female Gene Expression Regulation - genetics Gene Expression Regulation - immunology Gene Expression Regulation - radiation effects Humans Interleukin-17 - immunology Keratinocytes - immunology Keratinocytes - pathology Lectins, C-Type - genetics Lectins, C-Type - immunology Male Mice Mice, Knockout Receptors, Antigen, T-Cell, gamma-delta Regeneration - genetics Regeneration - immunology Regeneration - radiation effects T-Lymphocytes - immunology T-Lymphocytes - pathology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Ultraviolet Rays - adverse effects
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