Comparative Studies of Salivary and Blood Sialic Acid, Lipid Peroxidation and Antioxidative Status in Oral Squamous Cell Carcinoma (OSCC)
Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of or...
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| Veröffentlicht in: | Pakistan Journal of Medical Sciences 2014-05, Vol.30 (3), p.466-471 |
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| container_title | Pakistan Journal of Medical Sciences |
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| creator | Rasool, Mahmood Khan, Saima Rubab Malik, Arif Khan, Khalid Mahmood Zahid, Sara Manan, Abdul Qazi, Mahmood Husain Naseer, Muhammad Imran |
| description | Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva. |
| doi_str_mv | 10.12669/pjms.303.4985 |
| format | Article |
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The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.</description><identifier>ISSN: 1682-024X</identifier><identifier>ISSN: 1681-715X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.303.4985</identifier><identifier>PMID: 24948960</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Antioxidants ; Comparative analysis ; Lipid peroxidation ; Organic acids ; Original ; Squamous cell carcinoma</subject><ispartof>Pakistan Journal of Medical Sciences, 2014-05, Vol.30 (3), p.466-471</ispartof><rights>COPYRIGHT 2014 Knowledge Bylanes</rights><rights>Copyright AsiaNet Pakistan (Pvt) Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-75ec192e243ac2f1a415853dde06c789f9bbc6cf7ad8404aeb79208096ea79ab3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048487/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048487/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24948960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasool, Mahmood</creatorcontrib><creatorcontrib>Khan, Saima Rubab</creatorcontrib><creatorcontrib>Malik, Arif</creatorcontrib><creatorcontrib>Khan, Khalid Mahmood</creatorcontrib><creatorcontrib>Zahid, Sara</creatorcontrib><creatorcontrib>Manan, Abdul</creatorcontrib><creatorcontrib>Qazi, Mahmood Husain</creatorcontrib><creatorcontrib>Naseer, Muhammad Imran</creatorcontrib><title>Comparative Studies of Salivary and Blood Sialic Acid, Lipid Peroxidation and Antioxidative Status in Oral Squamous Cell Carcinoma (OSCC)</title><title>Pakistan Journal of Medical Sciences</title><addtitle>Pak J Med Sci</addtitle><description>Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.</description><subject>Antioxidants</subject><subject>Comparative analysis</subject><subject>Lipid peroxidation</subject><subject>Organic acids</subject><subject>Original</subject><subject>Squamous cell carcinoma</subject><issn>1682-024X</issn><issn>1681-715X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1r3DAQhk1padK01x6LoFBS6G4lWx_WJbA1_YKFLbiF3MRYkrNabGlj2UvzE_Kvq92kaVKCDhpGz7zSjN4se03wnOScy4_bTR_nBS7mVJbsSXZMeElmgrDzp4c4n-Gcnh9lL2LcYEw5Zfnz7CinkpaS4-Psugr9FgYY3c6iepyMsxGFFtXQuR0MVwi8QZ-6EAyqXcpptNDOfEBLt3UG_bBD-O1Mqg7-QC58Cm8yBz0Yp4icR6sBOlRfTtCHlKhs16EKBu186AGdruqqev8ye9ZCF-2r2_0k-_Xl88_q22y5-vq9WixnmhE-zgSzmsjc5rQAnbcEKGElK4yxmGtRylY2jea6FWBKiinYRsgcl1hyC0JCU5xkZze626nprdHWj-lxaju4PvWrAjj18MS7tboIO5XUSlqKJHB6KzCEy8nGUfUu6tQSeJu6U4QVkoo8wQl9-x-6CdPgU3uJYqwQTGD2j7qAzirn25Du1XtRtSiEoJJLXiZq_giVlrG908Hb1qX8g4J39wrWFrpxHUM37T8rPqqshxDjYNu7YRCsDi5Te5ep5DK1d1kqeHN_hHf4X1sVfwDFXs27</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Rasool, Mahmood</creator><creator>Khan, Saima Rubab</creator><creator>Malik, Arif</creator><creator>Khan, Khalid Mahmood</creator><creator>Zahid, Sara</creator><creator>Manan, Abdul</creator><creator>Qazi, Mahmood Husain</creator><creator>Naseer, Muhammad Imran</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publicaitons</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140501</creationdate><title>Comparative Studies of Salivary and Blood Sialic Acid, Lipid Peroxidation and Antioxidative Status in Oral Squamous Cell Carcinoma (OSCC)</title><author>Rasool, Mahmood ; Khan, Saima Rubab ; Malik, Arif ; Khan, Khalid Mahmood ; Zahid, Sara ; Manan, Abdul ; Qazi, Mahmood Husain ; Naseer, Muhammad Imran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-75ec192e243ac2f1a415853dde06c789f9bbc6cf7ad8404aeb79208096ea79ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antioxidants</topic><topic>Comparative analysis</topic><topic>Lipid peroxidation</topic><topic>Organic acids</topic><topic>Original</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasool, Mahmood</creatorcontrib><creatorcontrib>Khan, Saima Rubab</creatorcontrib><creatorcontrib>Malik, Arif</creatorcontrib><creatorcontrib>Khan, Khalid Mahmood</creatorcontrib><creatorcontrib>Zahid, Sara</creatorcontrib><creatorcontrib>Manan, Abdul</creatorcontrib><creatorcontrib>Qazi, Mahmood Husain</creatorcontrib><creatorcontrib>Naseer, Muhammad Imran</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan Journal of Medical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasool, Mahmood</au><au>Khan, Saima Rubab</au><au>Malik, Arif</au><au>Khan, Khalid Mahmood</au><au>Zahid, Sara</au><au>Manan, Abdul</au><au>Qazi, Mahmood Husain</au><au>Naseer, Muhammad Imran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Studies of Salivary and Blood Sialic Acid, Lipid Peroxidation and Antioxidative Status in Oral Squamous Cell Carcinoma (OSCC)</atitle><jtitle>Pakistan Journal of Medical Sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>30</volume><issue>3</issue><spage>466</spage><epage>471</epage><pages>466-471</pages><issn>1682-024X</issn><issn>1681-715X</issn><eissn>1681-715X</eissn><abstract>Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>24948960</pmid><doi>10.12669/pjms.303.4985</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Comparative analysis Lipid peroxidation Organic acids Original Squamous cell carcinoma |
| title | Comparative Studies of Salivary and Blood Sialic Acid, Lipid Peroxidation and Antioxidative Status in Oral Squamous Cell Carcinoma (OSCC) |
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