Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine

Cocaine use disorders are mediated by the cocaine blockade of the dopamine transporter in the central nervous system (CNS). On the basis of the concept that these effects could be obviated if cocaine were prevented from reaching its cognate receptors in the CNS, we have developed an anticocaine vacc...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Human gene therapy. Clinical development 2014-03, Vol.25 (1), p.40-49
Hauptverfasser:	Hicks, Martin J, Kaminsky, Stephen M, De, Bishnu P, Rosenberg, Jonathan B, Evans, Suzette M, Foltin, Richard W, Andrenyak, David M, Moody, David E, Koob, George F, Janda, Kim D, Ricart Arbona, Rodolfo J, Lepherd, Michelle L, Crystal, Ronald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Cocaine - analogs & derivatives Cocaine - blood Cocaine - pharmacology Cocaine-Related Disorders - therapy Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors Female Immunotherapy, Active Macaca mulatta Vaccination Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!