The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa

Retinitis pigmentosa (RP) is a group of inherited diseases that cause blindness due to the progressive death of rod and cone photoreceptors in the retina. There are currently no effective treatments for RP. Inherited mutations in rhodopsin, the light-sensing protein of rod photoreceptor cells, are t...

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Veröffentlicht in:	Cell death & disease 2014-05, Vol.5 (5), p.e1236-e1236
Hauptverfasser:	Parfitt, D A, Aguila, M, McCulley, C H, Bevilacqua, D, Mendes, H F, Athanasiou, D, Novoselov, S S, Kanuga, N, Munro, P M, Coffey, P J, Kalmar, B, Greensmith, L, Cheetham, M E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/470/1981 631/378/340 631/92/436 692/699/3161/3175 Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line Cell Survival - drug effects Cytoprotection Disease Models, Animal Dose-Response Relationship, Drug Electroretinography Heat-Shock Response - drug effects Humans Hydroxylamines - pharmacology Immunology Life Sciences Mutation Original original-article Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - metabolism Photoreceptor Cells, Vertebrate - pathology Rats Rats, Sprague-Dawley Rats, Transgenic Retinal Degeneration - genetics Retinal Degeneration - metabolism Retinal Degeneration - pathology Retinal Degeneration - physiopathology Retinal Degeneration - prevention & control Retinitis Pigmentosa - genetics Retinitis Pigmentosa - metabolism Retinitis Pigmentosa - pathology Retinitis Pigmentosa - physiopathology Retinitis Pigmentosa - prevention & control Rhodopsin - deficiency Rhodopsin - genetics Rhodopsin - metabolism Time Factors Transfection Unfolded Protein Response - drug effects Vision, Ocular - drug effects
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