Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island

Bacteroides fragilis causes the majority of anaerobic infections in humans. The presence of a pathogenicity island in the genome discriminates pathogenic and commensal B. fragilis strains. The island encodes metalloproteinase II (MPII), a potential virulence protein, and one of three homologous frag...

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Veröffentlicht in:	The FEBS journal 2014-06, Vol.281 (11), p.2487-2502
Hauptverfasser:	Shiryaev, Sergey A., Aleshin, Alexander E., Muranaka, Norihito, Kukreja, Muskan, Routenberg, David A., Remacle, Albert G., Liddington, Robert C., Cieplak, Piotr, Kozlov, Igor A., Strongin, Alex Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteroides fragilis Bacteroides fragilis - enzymology Bacteroides fragilis - genetics Bacteroides fragilis Biochemistry Enzymes Evolution Genomic Islands - genetics Metalloproteases - chemistry Metalloproteases - genetics metalloproteinases microbiome Pathogenesis pathogenicity Proteins structure
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