Allospecific Rejection of MHC Class I‐Deficient Bone Marrow by CD8 T Cells

Avoidance of long‐term immunosuppression is a desired goal in organ transplantation. Mixed chimerism offers a promising approach to tolerance induction, and we have aimed to develop low‐toxicity, nonimmunodepleting approaches to achieve this outcome. In a mouse model achieving fully MHC‐mismatched a...

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Veröffentlicht in:	American journal of transplantation 2014-01, Vol.14 (1), p.49-58
Hauptverfasser:	Haspot, F., Li, H. W., Lucas, C. L., Fehr, T., Beyaz, S., Sykes, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone marrow Bone Marrow - immunology Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction CD8 T cells CD8-Positive T-Lymphocytes - immunology H-2 Antigens - immunology Immune Tolerance - immunology indirect alloreactivity Isoantigens - immunology Lymphocytes Medical sciences Mice Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases tolerance Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Chimera Transplantation Conditioning Transplantation, Homologous Transplantation, Isogeneic Transplants & implants
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