IL-27R–Mediated Regulation of IL-17 Controls the Development of Respiratory Syncytial Virus–Associated Pathogenesis

IL-27 is a heterodimeric cytokine composed of the subunits p28 and Epstein-Barr virus induced gene (EBI)-3 and is known for its effects on T-cell function and differentiation. IL-27 signals through the widely expressed IL-27 receptor (IL-27R), composed of the ligand-specific IL-27Rα chain and gp130....

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Veröffentlicht in:	The American journal of pathology 2014-06, Vol.184 (6), p.1807-1818
Hauptverfasser:	de Almeida Nagata, Denise E, Demoor, Tine, Ptaschinski, Catherine, Ting, Hung-An, Jang, Sihyug, Reed, Michelle, Mukherjee, Sumanta, Lukacs, Nicholas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chloride Channels - genetics Chloride Channels - immunology Interleukin-17 - genetics Interleukin-17 - immunology Interleukins - genetics Interleukins - immunology Mice Mice, Knockout Minor Histocompatibility Antigens Mucin 5AC - genetics Mucin 5AC - immunology Mucoproteins - genetics Mucoproteins - immunology Mucus - immunology Pathology Receptors, Cytokine - genetics Receptors, Cytokine - immunology Regular Respiratory Syncytial Virus Infections - genetics Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - pathology Respiratory Syncytial Viruses - immunology STAT1 Transcription Factor - genetics STAT1 Transcription Factor - immunology Th17 Cells - immunology Th17 Cells - pathology Th2 Cells - immunology Th2 Cells - pathology
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