Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes

Six1, a member of the Six family of homeodomain transcription factors, is overexpressed in various human cancers, and SIX1 overexpression is associated with tumor progression and metastasis. Six1 messenger RNA levels increase during in vitro progression of human papillomavirus type 16 (HPV16)-immort...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-06, Vol.35 (6), p.1379-1388
Hauptverfasser:	Xu, Hanwen, Zhang, Yu, Altomare, Diego, Peña, Maria M, Wan, Fang, Pirisi, Lucia, Creek, Kim E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Transformed Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cell Transformation, Viral Cluster Analysis Disease Models, Animal Epithelial-Mesenchymal Transition - genetics Female Gene Expression Gene Expression Profiling HeLa Cells Heterografts Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human papillomavirus 16 - physiology Humans Keratinocytes - metabolism Keratinocytes - pathology Keratinocytes - virology MAP Kinase Signaling System Mice Neoplastic Stem Cells - metabolism Original Manuscript Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Signal Transduction Smad Proteins - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumor Burden - genetics
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