Estrogen receptor α in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3

The prostate cancer (PCa) microenvironment contains active stromal cells known as cancer-associated fibroblasts (CAF) that may play important roles in influencing tumor progression. Here we studied the role of CAF estrogen receptor alpha (ERα) and found that it could protect against PCa invasion. Im...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-06, Vol.35 (6), p.1301-1309
Hauptverfasser:	Slavin, Spencer, Yeh, Chiuan-Ren, Da, Jun, Yu, Shengqiang, Miyamoto, Hiroshi, Messing, Edward M, Guancial, Elizabeth, Yeh, Shuyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Estrogen Receptor alpha - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Heterografts Humans Immunohistochemistry Male Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - metabolism Neoplasm Invasiveness Original Manuscript Phenotype Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Protein Binding RNA Interference Stromal Cells - metabolism Stromal Cells - pathology Thrombospondins - genetics Thrombospondins - metabolism
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