Synbindin in Extracellular Signal-Regulated Protein Kinase Spatial Regulation and Gastric Cancer Aggressiveness

The molecular mechanisms that control the aggressiveness of gastric cancer (GC) remain poorly defined. Here we show that synbindin contributes to the aggressiveness of GC by activating extracellular signal-regulated protein kinase (ERK) signaling on the Golgi apparatus. Expression of synbindin was e...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2013-11, Vol.105 (22), p.1738-1749
Hauptverfasser:	XUAN KONG, JIN QIAN, WEIPING ZOU, JIE XU, FANG, Jing-Yuan, CHEN, Li-Sha, WANG, Ying-Chao, WANG, Ji-Lin, HAOYAN CHEN, WENG, Yu-Rong, ZHAO, Shu-Liang, JIE HONG, CHEN, Ying-Xuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor Chromatin Immunoprecipitation Flow Cytometry Fluorescence Resonance Energy Transfer Fluorescent Antibody Technique Gastric Mucosa - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Golgi Apparatus - enzymology Golgi Apparatus - metabolism Heterografts Humans Kaplan-Meier Estimate Luciferases Luminescent Agents MAP Kinase Kinase 1 - metabolism MAP Kinase Signaling System Medical sciences Mice Mice, Nude Mitogen-Activated Protein Kinase 1 - metabolism Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism NF-kappa B - metabolism Odds Ratio Phosphorylation Protein Array Analysis Retrospective Studies Stomach Neoplasms - enzymology Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcriptional Activation Tumors Up-Regulation Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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