A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) cell differentiation of antigen-stimulated CD4(+) T cells. Intriguingly, we found that Bcl6 was also highly and transiently expressed during the CD4(+)CD8(+) (double positive [DP]) stage of T cell development, in associ...

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Veröffentlicht in:	The Journal of experimental medicine 2014-06, Vol.211 (6), p.1137-1151
Hauptverfasser:	Mathew, Rebecca, Mao, Ai-ping, Chiang, Andrew H, Bertozzi-Villa, Clara, Bunker, Jeffrey J, Scanlon, Seth T, McDonald, Benjamin D, Constantinides, Michael G, Hollister, Kristin, Singer, Jeffrey D, Dent, Alexander L, Dinner, Aaron R, Bendelac, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - immunology Basic-Leucine Zipper Transcription Factors - metabolism Blotting, Western CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Cullin Proteins - genetics Cullin Proteins - immunology Cullin Proteins - metabolism Feedback, Physiological HeLa Cells Humans Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mice, Transgenic Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic - genetics Promoter Regions, Genetic - immunology Protein Binding - immunology Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-bcl-6 - immunology Proto-Oncogene Proteins c-bcl-6 - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Reverse Transcriptase Polymerase Chain Reaction Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Thymocytes - immunology Thymocytes - metabolism Transcriptome - immunology
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