Coping with dehydration: sympathetic activation and regulation of glutamatergic transmission in the hypothalamic PVN

Autonomic and endocrine profiles of chronic hypertension and heart failure resemble those of acute dehydration. Importantly, all of these conditions are associated with exaggerated sympathetic nerve activity (SNA) driven by glutamatergic activation of the hypothalamic paraventricular nucleus (PVN)....

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2014-06, Vol.306 (11), p.R804-R813
Hauptverfasser:	Bardgett, Megan E, Chen, Qing-Hui, Guo, Qing, Calderon, Alfredo S, Andrade, Mary Ann, Toney, Glenn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Psychological - physiology Animals Behavior, Animal - physiology Blood Pressure - drug effects Blood Pressure - physiology Cardiovascular disease Dehydration Dehydration - physiopathology Dose-Response Relationship, Drug Gene expression Glutamates - physiology Heart failure Homeostasis - physiology Hypertension Male Models, Animal N-Methylaspartate - pharmacology Neural Control Paraventricular Hypothalamic Nucleus - physiology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Synaptic Transmission - physiology
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