AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that controls cell proliferation, growth, survival, metabolism, and migration by activating the PI3K (phosphatidylinositol 3-kinase)-AKT and ERK (extracellular signal-regulated kinase)-RSK (ribosomal S6 kinase) pathways. EGF...

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Veröffentlicht in:	Science signaling 2013-06, Vol.6 (279), p.ra45-ra45
Hauptverfasser:	Er, Ekrem Emrah, Mendoza, Michelle C, Mackey, Ashley M, Rameh, Lucia E, Blenis, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line Endocytosis - drug effects Endosomes - metabolism Enzyme Activation - drug effects Epidermal Growth Factor - pharmacology HEK293 Cells Humans Lysosomes - metabolism Microscopy, Confocal Models, Biological Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Protein Transport - drug effects Proteolysis - drug effects Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism RNA Interference Signal Transduction - drug effects
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