Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells

Electron paramagnetic resonance (EPR) imaging is an emerging modality that can detect and localize paramagnetic molecular probes (so-called spin probes) in vivo. We previously demonstrated that nitroxide spin probes can be encapsulated in liposomes at concentrations exceeding 100 mM, at which nitrox...

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Veröffentlicht in:	Breast cancer research and treatment 2010-11, Vol.124 (1), p.121-131
Hauptverfasser:	Burks, Scott R, Macedo, Luciana F, Barth, Eugene D, Tkaczuk, Katherine H, Martin, Stuart S, Rosen, Gerald M, Halpern, Howard J, Brodie, Angela M, Kao, Joseph P. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Antibodies, Monoclonal, Humanized Biological and medical sciences Biological products Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Cancer research Cancer therapies Cell Line, Tumor electron paramagnetic resonance spectroscopy Electron Spin Resonance Spectroscopy - instrumentation Endocytosis Female Fluorescence Gynecology. Andrology. Obstetrics HER2 Humans image analysis Immunoglobulin Fab Fragments - metabolism Liposomes Mammary gland diseases Medical imaging Medical sciences Medicine Medicine & Public Health Metastasis Microscopy, Fluorescence Molecular Probes Nitrogen Oxides - metabolism Nitroxides Oncology Phantoms, Imaging Preclinical Study Receptor, ErbB-2 - genetics Receptor, ErbB-2 - immunology Receptor, ErbB-2 - metabolism Spin Labels Transfection Trastuzumab Tumors Up-Regulation
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