Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

In response to genotoxic stress the TP53 tumour suppressor activates target gene expression to induce cell cycle arrest or apoptosis depending on the extent of DNA damage. These canonical activities can be repressed by TP63 in normal stratifying epithelia to maintain proliferative capacity or drive...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2014-06, Vol.42 (10), p.6270-6285
Hauptverfasser:	McDade, Simon S, Patel, Daksha, Moran, Michael, Campbell, James, Fenwick, Kerry, Kozarewa, Iwanka, Orr, Nicholas J, Lord, Christopher J, Ashworth, Alan A, McCance, Dennis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cells, Cultured Cisplatin - toxicity DNA Breaks, Double-Stranded DNA Repair Doxorubicin - toxicity Gene regulation, Chromatin and Epigenetics Genome, Human Humans Keratinocytes - drug effects Keratinocytes - metabolism Mutagens - toxicity Stress, Physiological - genetics Transcription Factors - metabolism Transcription, Genetic Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!