SOCS3 Deletion in T-Lymphocytes Suppresses Development of Chronic Ocular Inflammation Via Up-regulation of CTLA-4 and Expansion of Regulatory T cells

Suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of JAK/STAT pathway and SOCS3 contributes to host immunity by regulating the intensity/duration of cytokine signals and inflammatory responses. Mice with Socs3 deletion in myeloid cells exhibit enhanced STAT3-signalin...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-10, Vol.191 (10), p.5036-5043
Hauptverfasser:	Yu, Cheng-Rong, Kim, Sung-Hye, Mahdi, Rashid M., Egwuagu, Charles E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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