γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

Angiogenesis is one of the key hallmarks of cancer. In this study, we investigated whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms. We observed that γ-tocotrienol inhibited vascular endothelial growt...

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Veröffentlicht in:	Oncotarget 2014-04, Vol.5 (7), p.1897-1911
Hauptverfasser:	Siveen, Kodappully Sivaraman, Ahn, Kwang Seok, Ong, Tina H., Shanmugam, Muthu K., Li, Feng, Yap, Wei Ney, Kumar, Alan Prem, Fong, Chee Wai, Tergaonkar, Vinay, Hui, Kam M, Sethi, Gautam
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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