Epigenetic reprogramming induces the expansion of cord blood stem cells

Cord blood (CB) cells that express CD34 have extensive hematopoietic capacity and rapidly divide ex vivo in the presence of cytokine combinations; however, many of these CB CD34+ cells lose their marrow-repopulating potential. To overcome this decline in function, we treated dividing CB CD34+ cells...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2014-06, Vol.124 (6), p.2378-2395
Hauptverfasser:	Chaurasia, Pratima, Gajzer, David C, Schaniel, Christoph, D'Souza, Sunita, Hoffman, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism Biomedical research Bone marrow Culture Media, Serum-Free Cytokines Cytokines - pharmacology Divisions Epigenesis, Genetic - drug effects Epigenetic inheritance Epigenetics Expansion Fetal blood Fetal Blood - cytology Fetal Blood - metabolism Fetal Blood - transplantation Hematology Hematopoiesis - drug effects Hematopoiesis - genetics Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Heterografts Histone Deacetylase Inhibitors - pharmacology Humans Mice Mice, SCID Properties RNA, Small Interfering - genetics Software Stem cells Technical Advance Thy-1 Antigens - metabolism Transplantation Valproic Acid - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!