A dual role of the transcriptional regulator TstR provides insights into cyanide detoxification in Lactobacillus brevis

Summary In this study we uncover two genes in Lactobacillus brevis ATCC 367, tstT and tstR, encoding for a rhodanese and a transcriptional regulator involved in cyanide detoxification. TstT (LVIS_0852) belongs to a new class of thiosulphate:cyanide sulphurtransferases. We found that TstR (LVIS_0853)...

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Veröffentlicht in:	Molecular microbiology 2014-05, Vol.92 (4), p.853-871
Hauptverfasser:	Pagliai, Fernando A., Murdoch, Caitlin C., Brown, Sara M., Gonzalez, Claudio F., Lorca, Graciela L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biotransformation Cloning, Molecular Cyanides - metabolism Drug Tolerance E coli Electrophoretic Mobility Shift Assay Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Ferric Compounds - metabolism Gene Expression Gene Expression Regulation, Bacterial Genes Lactobacillus Lactobacillus brevis Lactobacillus brevis - drug effects Lactobacillus brevis - metabolism Mutagenesis Mutagenesis, Site-Directed Probiotics Promoter Regions, Genetic Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism RNA-protein interactions Sulfites - metabolism Thiosulfate Sulfurtransferase - genetics Thiosulfate Sulfurtransferase - metabolism Transcription Initiation Site Transcription, Genetic
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