Bone Marrow Transplantation Helps Restore the Intestinal Mucosal Barrier after Total Body Irradiation in Mice

Bone marrow transplantation (BMT) substantially improves 10-day survival after total body irradiation (TBI), consistent with an effect on intestinal radiation death. Total body irradiation, in addition to injuring the intestinal epithelium, also perturbs the mucosal immune system, the largest immune...

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Veröffentlicht in:	Radiation research 2014-03, Vol.181 (3), p.229-239
Hauptverfasser:	Garg, Sarita, Wang, Wenze, Prabath, Biju G, Boerma, Marjan, Wang, Junru, Zhou, Daohong, Hauer-Jensen, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Blood Cell Count Bone marrow Bone Marrow Transplantation Chemokines - metabolism Epithelial cells Immune system Interleukin-10 - biosynthesis Interleukin-12 - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Intestines Irradiation Jejunum Jejunum - immunology Jejunum - radiation effects Lymphocytes Male Mice Permeability - radiation effects Physical trauma Radiation injuries Radiation Injuries - blood Radiation Injuries - immunology Radiation Injuries - metabolism Radiation Injuries - surgery REGULAR ARTICLES Tight Junctions - metabolism Tight Junctions - radiation effects Transplantation Traumatic brain injury Whole-Body Irradiation - adverse effects
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