Active angiogenesis in metastatic renal cell carcinoma predicts clinical benefit to sunitinib-based therapy

Background: Sunitinib represents a widely used therapy for metastatic renal cell carcinoma patients. Even so, there is a group of patients who show toxicity without clinical benefit. In this work, we have analysed pivotal molecular targets involved in angiogenesis (vascular endothelial growth factor...

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Veröffentlicht in:	British journal of cancer 2014-05, Vol.110 (11), p.2700-2707
Hauptverfasser:	del Puerto-Nevado, L, Rojo, F, Zazo, S, Caramés, C, Rubio, G, Vega, R, Chamizo, C, Casado, V, Martínez-Useros, J, Rincón, R, Rodríguez-Remírez, M, Borrero-Palacios, A, Cristóbal, I, Madoz-Gúrpide, J, Aguilera, O, García-Foncillas, J
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2423 692/699/67/2328 692/699/67/589/1588/1351 692/700/565/1436 Adult Aged Aged, 80 and over Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Biological and medical sciences Biomarkers Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Biopsy Cancer Research Carcinoma, Renal Cell - blood supply Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary Cohort Studies Disease-Free Survival Drug Resistance Epidemiology Female Hospitals Humans Indoles - pharmacology Indoles - therapeutic use Kaplan-Meier Estimate Kidney cancer Kidney Neoplasms - blood supply Kidney Neoplasms - drug therapy Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidneys Male Medical research Medical sciences Metastasis Microvessels - pathology Middle Aged Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Multivariate Analysis Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Nephrology. Urinary tract diseases Oncology Patients Phosphoproteins - metabolism Proportional Hazards Models Pyrroles - pharmacology Pyrroles - therapeutic use Toxicity Tumors Tumors of the urinary system Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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