Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 is a hypermutable contingency locus

The ALS (agglutinin-like sequence) gene family encodes proteins that play a role in adherence of the yeast Candida albicans to endothelial and epithelial cells. The proteins are proposed as virulence factors for this important fungal pathogen of humans. We analyzed 66 C. albicans strains, representi...

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Veröffentlicht in:	Genome research 2003-09, Vol.13 (9), p.2005-2017
Hauptverfasser:	Zhang, Ningxin, Harrex, Annette L, Holland, Barbara R, Fenton, Lauren E, Cannon, Richard D, Schmid, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Candida albicans - genetics Conserved Sequence - genetics Fungal Proteins - biosynthesis Fungal Proteins - genetics Gene Expression Regulation, Fungal - genetics Genetic Markers Genetic Variation Genotype Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Molecular Sequence Data Multigene Family Mutation Open Reading Frames - genetics Polymorphism, Restriction Fragment Length RNA, Messenger - analysis Species Specificity Tandem Repeat Sequences - genetics
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