Crystal Structure and Molecular Imaging of the Nav Channel β3 Subunit Indicates a Trimeric Assembly

The vertebrate sodium (Nav) channel is composed of an ion-conducting α subunit and associated β subunits. Here, we report the crystal structure of the human β3 subunit immunoglobulin (Ig) domain, a functionally important component of Nav channels in neurons and cardiomyocytes. Surprisingly, we found...

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Veröffentlicht in:	The Journal of biological chemistry 2014-04, Vol.289 (15), p.10797-10811
Hauptverfasser:	Namadurai, Sivakumar, Balasuriya, Dilshan, Rajappa, Rajit, Wiemhöfer, Martin, Stott, Katherine, Klingauf, Jurgen, Edwardson, J.Michael, Chirgadze, Dimitri Y., Jackson, Antony P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical Ultracentrifugation Atomic Force Microscopy Binding Sites Cloning, Molecular Crystallization Crystallography, X-Ray Dimerization HEK293 Cells Humans Immunoglobulins - chemistry In Vivo Imaging Microscopy, Atomic Force Molecular Sequence Data NAV1.5 Voltage-Gated Sodium Channel - chemistry Photoactivated Localization Microscopy Protein Conformation Protein Structure and Folding Protein Trimerization Sodium Channels Ultracentrifugation Voltage-Gated Sodium Channel beta-3 Subunit - chemistry X-ray Crystallography
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