Ovarian Cancer Cell Heparan Sulfate 6-O-Sulfotransferases Regulate an Angiogenic Program Induced by Heparin-binding Epidermal Growth Factor (EGF)-like Growth Factor/EGF Receptor Signaling

Heparan sulfate (HS) is a component of cell surface and extracellular matrix proteoglycans that regulates numerous signaling pathways by binding and activating multiple growth factors and chemokines. The amount and pattern of HS sulfation are key determinants for the assembly of the trimolecular, HS...

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Veröffentlicht in:	The Journal of biological chemistry 2014-04, Vol.289 (15), p.10488-10501
Hauptverfasser:	Cole, Claire L., Rushton, Graham, Jayson, Gordon C., Avizienyte, Egle
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cell Line, Tumor Culture Media, Conditioned - chemistry Cytokines - metabolism Disaccharides - metabolism Epidermal Growth Factor - metabolism Epidermal Growth Factor Receptor (EGFR) ErbB Receptors - metabolism Female Fibroblast Growth Factor 2 - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glucosamine - metabolism HB-EGF Heparan Sulfate Humans IL-6 IL-8 Interleukin-6 - metabolism Interleukin-8 - metabolism Mice Mice, Inbred NOD Molecular Bases of Disease Neoplasm Transplantation Neovascularization, Pathologic Ovarian Neoplasms - metabolism Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Signal Transduction Sulfotransferase Sulfotransferases - metabolism Tumor Microenvironment
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