The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits
Background The aim of this study was to assess the influence of propranolol, nebivolol, and carvedilol on intraocular pressure and blood flow in vessels of rabbit’s (New Zealand White) eyeball. Methods The study was carried out on New Zealand white rabbits. Intraocular pressure was measured with the...
Gespeichert in:
| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2014-06, Vol.252 (6), p.917-923 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 923 |
|---|---|
| container_issue | 6 |
| container_start_page | 917 |
| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 252 |
| creator | Szumny, Dorota Szeląg, Adam |
| description | Background
The aim of this study was to assess the influence of propranolol, nebivolol, and carvedilol on intraocular pressure and blood flow in vessels of rabbit’s (New Zealand White) eyeball.
Methods
The study was carried out on New Zealand white rabbits. Intraocular pressure was measured with the applanation tonometer Möller–Wedel and Icare; blood flow was measured with Doppler Laser Blood Flow Monitor MBD3.
Results
Following a single administration into a conjunctival sac, all drugs decreased intraocular pressure. Iris blood flow was decreased following administration of propranol, but increased by nebivolol and carvedilol. After single and repeated oral administration of nebivolol and carvedilol an IOP decrease was demonstrated, but with no effect of all applied doses on iris or retina/choroid blood flow.
Conclusion
Studies performed on an animal model indicate that it is possible to reduce the intraocular pressure and increase ocular blood flow in humans, following topical administration of carvedilol and nebivolol. Confirmation of those results in clinical trials may lead to development of a new anti-glaucoma treatment. Further clinical studies of long-term nebivolol and carvedilol are recommended. They are necessary for evaluation of usefulness of those drugs for selected groups of patients, for example those with glaucoma and arterial hypertension. |
| doi_str_mv | 10.1007/s00417-014-2623-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4035558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3319189871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-4841a3726f107386c491ec28e6fb9eb1df9f62bd7ceba49f529b22787c0d69a63</originalsourceid><addsrcrecordid>eNp1kU9rFTEUxYMo9ln9AG4k4Dqav5OZjSCltkLBTYXuQpK5aVPS5JnMvNJvb56vlrpwFW7u75x74CD0ntFPjFL9uVEqmSaUScIHLoh6gTZMCkU05Vcv0YZqzsgo-NURetPaLe24UOw1OuJSUzUqvkG7yxvAMYe0QvaAS8AZ7rGDxRI7V8glPSzRt_7r4q6kkrDNM_a27mCO-7HkLl-qLX5NtuJthdbWCn-wWGPDLpUy45DKfQdxtc7Fpb1Fr4JNDd49vsfo57fTy5NzcvHj7PvJ1wvie8KFyFEyKzQfAqNajIOXEwPPRxiCm8CxOUxh4G7WHpyVU1B8cpzrUXs6D5MdxDH6cvDdru4OZg_7qMlsa7yz9cEUG82_mxxvzHXZGUmFUmrsBh8fDWr5tUJbzG1Za-6ZDVOCCjoO09QpdqB8La1VCE8XGDX7qsyhKtOrMvuqjOqaD8-jPSn-dtMBfgBaX-VrqM9O_9f1N77Roec</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1530308699</pqid></control><display><type>article</type><title>The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Szumny, Dorota ; Szeląg, Adam</creator><creatorcontrib>Szumny, Dorota ; Szeląg, Adam</creatorcontrib><description>Background
The aim of this study was to assess the influence of propranolol, nebivolol, and carvedilol on intraocular pressure and blood flow in vessels of rabbit’s (New Zealand White) eyeball.
Methods
The study was carried out on New Zealand white rabbits. Intraocular pressure was measured with the applanation tonometer Möller–Wedel and Icare; blood flow was measured with Doppler Laser Blood Flow Monitor MBD3.
Results
Following a single administration into a conjunctival sac, all drugs decreased intraocular pressure. Iris blood flow was decreased following administration of propranol, but increased by nebivolol and carvedilol. After single and repeated oral administration of nebivolol and carvedilol an IOP decrease was demonstrated, but with no effect of all applied doses on iris or retina/choroid blood flow.
Conclusion
Studies performed on an animal model indicate that it is possible to reduce the intraocular pressure and increase ocular blood flow in humans, following topical administration of carvedilol and nebivolol. Confirmation of those results in clinical trials may lead to development of a new anti-glaucoma treatment. Further clinical studies of long-term nebivolol and carvedilol are recommended. They are necessary for evaluation of usefulness of those drugs for selected groups of patients, for example those with glaucoma and arterial hypertension.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-014-2623-5</identifier><identifier>PMID: 24705852</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject><![CDATA[Administration, Oral ; Administration, Topical ; Adrenergic beta-1 Receptor Antagonists - administration & dosage ; Adrenergic beta-1 Receptor Antagonists - pharmacology ; Animals ; Antihypertensive Agents - administration & dosage ; Antihypertensive Agents - pharmacology ; Basic Science ; Benzopyrans - administration & dosage ; Benzopyrans - pharmacology ; Blood Flow Velocity - drug effects ; Carbazoles - administration & dosage ; Carbazoles - pharmacology ; Ethanolamines - administration & dosage ; Ethanolamines - pharmacology ; Female ; Intraocular Pressure - drug effects ; Iris - blood supply ; Male ; Medicine ; Medicine & Public Health ; Nebivolol ; Ophthalmic Solutions ; Ophthalmology ; Propanolamines - administration & dosage ; Propanolamines - pharmacology ; Propranolol - administration & dosage ; Propranolol - pharmacology ; Rabbits ; Regional Blood Flow - drug effects ; Tonometry, Ocular]]></subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2014-06, Vol.252 (6), p.917-923</ispartof><rights>The Author(s) 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-4841a3726f107386c491ec28e6fb9eb1df9f62bd7ceba49f529b22787c0d69a63</citedby><cites>FETCH-LOGICAL-c470t-4841a3726f107386c491ec28e6fb9eb1df9f62bd7ceba49f529b22787c0d69a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-014-2623-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-014-2623-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24705852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szumny, Dorota</creatorcontrib><creatorcontrib>Szeląg, Adam</creatorcontrib><title>The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Background
The aim of this study was to assess the influence of propranolol, nebivolol, and carvedilol on intraocular pressure and blood flow in vessels of rabbit’s (New Zealand White) eyeball.
Methods
The study was carried out on New Zealand white rabbits. Intraocular pressure was measured with the applanation tonometer Möller–Wedel and Icare; blood flow was measured with Doppler Laser Blood Flow Monitor MBD3.
Results
Following a single administration into a conjunctival sac, all drugs decreased intraocular pressure. Iris blood flow was decreased following administration of propranol, but increased by nebivolol and carvedilol. After single and repeated oral administration of nebivolol and carvedilol an IOP decrease was demonstrated, but with no effect of all applied doses on iris or retina/choroid blood flow.
Conclusion
Studies performed on an animal model indicate that it is possible to reduce the intraocular pressure and increase ocular blood flow in humans, following topical administration of carvedilol and nebivolol. Confirmation of those results in clinical trials may lead to development of a new anti-glaucoma treatment. Further clinical studies of long-term nebivolol and carvedilol are recommended. They are necessary for evaluation of usefulness of those drugs for selected groups of patients, for example those with glaucoma and arterial hypertension.</description><subject>Administration, Oral</subject><subject>Administration, Topical</subject><subject>Adrenergic beta-1 Receptor Antagonists - administration & dosage</subject><subject>Adrenergic beta-1 Receptor Antagonists - pharmacology</subject><subject>Animals</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Basic Science</subject><subject>Benzopyrans - administration & dosage</subject><subject>Benzopyrans - pharmacology</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Carbazoles - administration & dosage</subject><subject>Carbazoles - pharmacology</subject><subject>Ethanolamines - administration & dosage</subject><subject>Ethanolamines - pharmacology</subject><subject>Female</subject><subject>Intraocular Pressure - drug effects</subject><subject>Iris - blood supply</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nebivolol</subject><subject>Ophthalmic Solutions</subject><subject>Ophthalmology</subject><subject>Propanolamines - administration & dosage</subject><subject>Propanolamines - pharmacology</subject><subject>Propranolol - administration & dosage</subject><subject>Propranolol - pharmacology</subject><subject>Rabbits</subject><subject>Regional Blood Flow - drug effects</subject><subject>Tonometry, Ocular</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9rFTEUxYMo9ln9AG4k4Dqav5OZjSCltkLBTYXuQpK5aVPS5JnMvNJvb56vlrpwFW7u75x74CD0ntFPjFL9uVEqmSaUScIHLoh6gTZMCkU05Vcv0YZqzsgo-NURetPaLe24UOw1OuJSUzUqvkG7yxvAMYe0QvaAS8AZ7rGDxRI7V8glPSzRt_7r4q6kkrDNM_a27mCO-7HkLl-qLX5NtuJthdbWCn-wWGPDLpUy45DKfQdxtc7Fpb1Fr4JNDd49vsfo57fTy5NzcvHj7PvJ1wvie8KFyFEyKzQfAqNajIOXEwPPRxiCm8CxOUxh4G7WHpyVU1B8cpzrUXs6D5MdxDH6cvDdru4OZg_7qMlsa7yz9cEUG82_mxxvzHXZGUmFUmrsBh8fDWr5tUJbzG1Za-6ZDVOCCjoO09QpdqB8La1VCE8XGDX7qsyhKtOrMvuqjOqaD8-jPSn-dtMBfgBaX-VrqM9O_9f1N77Roec</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Szumny, Dorota</creator><creator>Szeląg, Adam</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20140601</creationdate><title>The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits</title><author>Szumny, Dorota ; Szeląg, Adam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-4841a3726f107386c491ec28e6fb9eb1df9f62bd7ceba49f529b22787c0d69a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Administration, Topical</topic><topic>Adrenergic beta-1 Receptor Antagonists - administration & dosage</topic><topic>Adrenergic beta-1 Receptor Antagonists - pharmacology</topic><topic>Animals</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Basic Science</topic><topic>Benzopyrans - administration & dosage</topic><topic>Benzopyrans - pharmacology</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Carbazoles - administration & dosage</topic><topic>Carbazoles - pharmacology</topic><topic>Ethanolamines - administration & dosage</topic><topic>Ethanolamines - pharmacology</topic><topic>Female</topic><topic>Intraocular Pressure - drug effects</topic><topic>Iris - blood supply</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nebivolol</topic><topic>Ophthalmic Solutions</topic><topic>Ophthalmology</topic><topic>Propanolamines - administration & dosage</topic><topic>Propanolamines - pharmacology</topic><topic>Propranolol - administration & dosage</topic><topic>Propranolol - pharmacology</topic><topic>Rabbits</topic><topic>Regional Blood Flow - drug effects</topic><topic>Tonometry, Ocular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szumny, Dorota</creatorcontrib><creatorcontrib>Szeląg, Adam</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szumny, Dorota</au><au>Szeląg, Adam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>252</volume><issue>6</issue><spage>917</spage><epage>923</epage><pages>917-923</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Background
The aim of this study was to assess the influence of propranolol, nebivolol, and carvedilol on intraocular pressure and blood flow in vessels of rabbit’s (New Zealand White) eyeball.
Methods
The study was carried out on New Zealand white rabbits. Intraocular pressure was measured with the applanation tonometer Möller–Wedel and Icare; blood flow was measured with Doppler Laser Blood Flow Monitor MBD3.
Results
Following a single administration into a conjunctival sac, all drugs decreased intraocular pressure. Iris blood flow was decreased following administration of propranol, but increased by nebivolol and carvedilol. After single and repeated oral administration of nebivolol and carvedilol an IOP decrease was demonstrated, but with no effect of all applied doses on iris or retina/choroid blood flow.
Conclusion
Studies performed on an animal model indicate that it is possible to reduce the intraocular pressure and increase ocular blood flow in humans, following topical administration of carvedilol and nebivolol. Confirmation of those results in clinical trials may lead to development of a new anti-glaucoma treatment. Further clinical studies of long-term nebivolol and carvedilol are recommended. They are necessary for evaluation of usefulness of those drugs for selected groups of patients, for example those with glaucoma and arterial hypertension.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24705852</pmid><doi>10.1007/s00417-014-2623-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2014-06, Vol.252 (6), p.917-923 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4035558 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Administration, Oral Administration, Topical Adrenergic beta-1 Receptor Antagonists - administration & dosage Adrenergic beta-1 Receptor Antagonists - pharmacology Animals Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacology Basic Science Benzopyrans - administration & dosage Benzopyrans - pharmacology Blood Flow Velocity - drug effects Carbazoles - administration & dosage Carbazoles - pharmacology Ethanolamines - administration & dosage Ethanolamines - pharmacology Female Intraocular Pressure - drug effects Iris - blood supply Male Medicine Medicine & Public Health Nebivolol Ophthalmic Solutions Ophthalmology Propanolamines - administration & dosage Propanolamines - pharmacology Propranolol - administration & dosage Propranolol - pharmacology Rabbits Regional Blood Flow - drug effects Tonometry, Ocular |
| title | The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T18%3A33%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20influence%20of%20new%20beta-adrenolytics%20nebivolol%20and%20carvedilol%20on%20intraocular%20pressure%20and%20iris%20blood%20flow%20in%20rabbits&rft.jtitle=Graefe's%20archive%20for%20clinical%20and%20experimental%20ophthalmology&rft.au=Szumny,%20Dorota&rft.date=2014-06-01&rft.volume=252&rft.issue=6&rft.spage=917&rft.epage=923&rft.pages=917-923&rft.issn=0721-832X&rft.eissn=1435-702X&rft_id=info:doi/10.1007/s00417-014-2623-5&rft_dat=%3Cproquest_pubme%3E3319189871%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1530308699&rft_id=info:pmid/24705852&rfr_iscdi=true |