Protective Effects of C‐Type Natriuretic Peptide on Linear Growth and Articular Cartilage Integrity in a Mouse Model of Inflammatory Arthritis

Objective The C‐type natriuretic peptide (CNP) signaling pathway is a major contributor to postnatal skeletal growth in humans. This study was undertaken to investigate whether CNP signaling could prevent growth delay and cartilage damage in an animal model of inflammatory arthritis. Methods We gene...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2014-01, Vol.66 (1), p.78-89
Hauptverfasser:	Bükülmez, Hülya, Khan, Fozia, Bartels, Cynthia F., Murakami, Shunichi, Ortiz‐Lopez, Adriana, Sattar, Abdus, Haqqi, Tariq M., Warman, Matthew L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Arthritis, Experimental - metabolism Arthritis, Experimental - physiopathology Arthritis, Juvenile - metabolism Arthritis, Juvenile - physiopathology Bone Development - physiology Cartilage, Articular - growth & development Cartilage, Articular - metabolism Cell Differentiation Cell Proliferation Chondrocytes - metabolism Chondrocytes - physiology Experimental Arthritis Mice Mice, Transgenic Natriuretic Peptide, C-Type - metabolism Natriuretic Peptide, C-Type - physiology Rodents Signal Transduction - physiology T cell receptors Transgenic animals
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