The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration

Cell migration is mediated by the dynamic remodeling of focal adhesions (FAs). Recently, an important role of endosomal signaling in regulation of cell migration was recognized. Here, we show an essential function for late endosomes carrying the p14-MP1 (LAMTOR2/3) complex in FA dynamics. p14-MP1-po...

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Veröffentlicht in:	The Journal of cell biology 2014-05, Vol.205 (4), p.525-540
Hauptverfasser:	Schiefermeier, Natalia, Scheffler, Julia M, de Araujo, Mariana E G, Stasyk, Taras, Yordanov, Teodor, Ebner, Hannes L, Offterdinger, Martin, Munck, Sebastian, Hess, Michael W, Wickström, Sara A, Lange, Anika, Wunderlich, Winfried, Fässler, Reinhard, Teis, David, Huber, Lukas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism ADP-Ribosylation Factors - metabolism Animals Cell adhesion & migration Cell Line Cell Movement - physiology Endosomes - metabolism Fibroblasts - cytology Focal Adhesions - metabolism Genetics HeLa Cells Humans Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data NIH 3T3 Cells Proteins - genetics Proteins - metabolism ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Rodents Signal Transduction - physiology
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