Spinal Inflammation in the Absence of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in Patients With Active Nonradiographic Axial Spondyloarthritis
Objective To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups. Methods ABILITY‐1 is...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2014-03, Vol.66 (3), p.667-673 |
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| creator | Heijde, Désirée Sieper, Joachim Maksymowych, Walter P. Brown, Matthew A. Lambert, Robert G. W. Rathmann, Suchitrita S. Pangan, Aileen L. |
| description | Objective
To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups.
Methods
ABILITY‐1 is a multicenter, randomized, controlled trial of adalimumab versus placebo in patients with nonradiographic axial SpA classified using the Assessment of SpondyloArthritis international Society axial SpA criteria. Baseline MRIs were centrally scored independently by 2 readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) method for the SI joints and the SPARCC 6–discovertebral unit method for the spine. Positive evidence of inflammation on MRI was defined as a SPARCC score of ≥2 for either the SI joints or the spine.
Results
Among patients with baseline SPARCC scores, 40% had an SI joint score of ≥2 and 52% had a spine score of ≥2. Forty‐nine percent of patients with baseline SI joint scores of |
| doi_str_mv | 10.1002/art.38283 |
| format | Article |
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To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups.
Methods
ABILITY‐1 is a multicenter, randomized, controlled trial of adalimumab versus placebo in patients with nonradiographic axial SpA classified using the Assessment of SpondyloArthritis international Society axial SpA criteria. Baseline MRIs were centrally scored independently by 2 readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) method for the SI joints and the SPARCC 6–discovertebral unit method for the spine. Positive evidence of inflammation on MRI was defined as a SPARCC score of ≥2 for either the SI joints or the spine.
Results
Among patients with baseline SPARCC scores, 40% had an SI joint score of ≥2 and 52% had a spine score of ≥2. Forty‐nine percent of patients with baseline SI joint scores of <2, and 58% of those with baseline SI joint scores of ≥2, had a spine score of ≥2. Comparison of baseline disease characteristics by baseline SI joint and spine scores showed that a greater proportion of patients in the subgroup with a baseline SPARCC score of ≥2 for both SI joints and spine were male, and patients with spine and SI joint scores of <2 were younger and had shorter symptom duration. SPARCC spine scores correlated with baseline symptom duration, and SI joint scores correlated negatively with the baseline Bath Ankylosing Spondylitis Disease Activity Index, but neither correlated with the baseline Ankylosing Spondylitis Disease Activity Score, total back pain, the patient's global assessment of disease activity, the Bath Ankylosing Spondylitis Functional Index, morning stiffness, nocturnal pain, or C‐reactive protein level.
Conclusion
Assessment by experienced readers showed that spinal inflammation on MRI might be observed in half of patients with nonradiographic axial SpA without SI joint inflammation.</description><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.38283</identifier><identifier>PMID: 24574227</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adalimumab ; Adult ; Aged ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antirheumatic Agents - therapeutic use ; Female ; Humans ; Inflammation ; Inflammation - complications ; Inflammation - pathology ; Male ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Sacroiliitis - complications ; Sacroiliitis - pathology ; Severity of Illness Index ; Spine - pathology ; Spondylarthritis - complications ; Spondylarthritis - drug therapy ; Spondylarthritis - pathology ; Spondyloarthritis ; Treatment Outcome</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2014-03, Vol.66 (3), p.667-673</ispartof><rights>2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.</rights><rights>Copyright © 2014 by the American College of Rheumatology</rights><rights>2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4433-14a3ceaebfd2d84ab14d2ee5b52213549914e2d41b1865948039a31a495cf42c3</citedby><cites>FETCH-LOGICAL-c4433-14a3ceaebfd2d84ab14d2ee5b52213549914e2d41b1865948039a31a495cf42c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.38283$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.38283$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24574227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heijde, Désirée</creatorcontrib><creatorcontrib>Sieper, Joachim</creatorcontrib><creatorcontrib>Maksymowych, Walter P.</creatorcontrib><creatorcontrib>Brown, Matthew A.</creatorcontrib><creatorcontrib>Lambert, Robert G. W.</creatorcontrib><creatorcontrib>Rathmann, Suchitrita S.</creatorcontrib><creatorcontrib>Pangan, Aileen L.</creatorcontrib><title>Spinal Inflammation in the Absence of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in Patients With Active Nonradiographic Axial Spondyloarthritis</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheumatol</addtitle><description>Objective
To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups.
Methods
ABILITY‐1 is a multicenter, randomized, controlled trial of adalimumab versus placebo in patients with nonradiographic axial SpA classified using the Assessment of SpondyloArthritis international Society axial SpA criteria. Baseline MRIs were centrally scored independently by 2 readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) method for the SI joints and the SPARCC 6–discovertebral unit method for the spine. Positive evidence of inflammation on MRI was defined as a SPARCC score of ≥2 for either the SI joints or the spine.
Results
Among patients with baseline SPARCC scores, 40% had an SI joint score of ≥2 and 52% had a spine score of ≥2. Forty‐nine percent of patients with baseline SI joint scores of <2, and 58% of those with baseline SI joint scores of ≥2, had a spine score of ≥2. Comparison of baseline disease characteristics by baseline SI joint and spine scores showed that a greater proportion of patients in the subgroup with a baseline SPARCC score of ≥2 for both SI joints and spine were male, and patients with spine and SI joint scores of <2 were younger and had shorter symptom duration. SPARCC spine scores correlated with baseline symptom duration, and SI joint scores correlated negatively with the baseline Bath Ankylosing Spondylitis Disease Activity Index, but neither correlated with the baseline Ankylosing Spondylitis Disease Activity Score, total back pain, the patient's global assessment of disease activity, the Bath Ankylosing Spondylitis Functional Index, morning stiffness, nocturnal pain, or C‐reactive protein level.
Conclusion
Assessment by experienced readers showed that spinal inflammation on MRI might be observed in half of patients with nonradiographic axial SpA without SI joint inflammation.</description><subject>Adalimumab</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal, Humanized - therapeutic use</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Sacroiliitis - complications</subject><subject>Sacroiliitis - pathology</subject><subject>Severity of Illness Index</subject><subject>Spine - pathology</subject><subject>Spondylarthritis - complications</subject><subject>Spondylarthritis - drug therapy</subject><subject>Spondylarthritis - pathology</subject><subject>Spondyloarthritis</subject><subject>Treatment Outcome</subject><issn>2326-5191</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EolXpghdAllixmNa_k2SDFFVAB5UfdYpYWjeOk7hK7NT2lM7j8KZ4mLaiCyxLtuTvHp97D0KvKTmhhLBTCOmEl6zkz9Ah42y5kIzI5w93WtEDdBzjNcmrKsiSyJfogAlZCMaKQ_R7PVsHI165boRpgmS9w9bhNBhcN9E4bbDv8Bp08Ha0oPFnb116yuf9BXpnktX40kTvYFe2mqC3rt-pfc-ccSninzYNuNbJ3hr81bsArfV9gHnIlfWdzUbWs3ftdvS5rSHYZOMr9KKDMZrj-_MI_fj44ersfHHx7dPqrL5YaCE4X1ABXBswTdeythTQUNEyY2QjGaNciqqiwrBW0IaWS1mJkvAKOAVRSd0JpvkRer_XnTfNZFqd_QYY1RzsBGGrPFj19MXZQfX-VgnCuSxYFnh7LxD8zcbEpK79JuThRkULyVlF-LLM1Ls9lQcaYzDd4w-UqF2gKneu_gaa2Tf_WnokH-LLwOke-GVHs_2_kqovr_aSfwASZa3B</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Heijde, Désirée</creator><creator>Sieper, Joachim</creator><creator>Maksymowych, Walter P.</creator><creator>Brown, Matthew A.</creator><creator>Lambert, Robert G. W.</creator><creator>Rathmann, Suchitrita S.</creator><creator>Pangan, Aileen L.</creator><general>Wiley Subscription Services, Inc</general><general>BlackWell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201403</creationdate><title>Spinal Inflammation in the Absence of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in Patients With Active Nonradiographic Axial Spondyloarthritis</title><author>Heijde, Désirée ; Sieper, Joachim ; Maksymowych, Walter P. ; Brown, Matthew A. ; Lambert, Robert G. W. ; Rathmann, Suchitrita S. ; Pangan, Aileen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4433-14a3ceaebfd2d84ab14d2ee5b52213549914e2d41b1865948039a31a495cf42c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adalimumab</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Monoclonal, Humanized - therapeutic use</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Sacroiliitis - complications</topic><topic>Sacroiliitis - pathology</topic><topic>Severity of Illness Index</topic><topic>Spine - pathology</topic><topic>Spondylarthritis - complications</topic><topic>Spondylarthritis - drug therapy</topic><topic>Spondylarthritis - pathology</topic><topic>Spondyloarthritis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heijde, Désirée</creatorcontrib><creatorcontrib>Sieper, Joachim</creatorcontrib><creatorcontrib>Maksymowych, Walter P.</creatorcontrib><creatorcontrib>Brown, Matthew A.</creatorcontrib><creatorcontrib>Lambert, Robert G. W.</creatorcontrib><creatorcontrib>Rathmann, Suchitrita S.</creatorcontrib><creatorcontrib>Pangan, Aileen L.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heijde, Désirée</au><au>Sieper, Joachim</au><au>Maksymowych, Walter P.</au><au>Brown, Matthew A.</au><au>Lambert, Robert G. W.</au><au>Rathmann, Suchitrita S.</au><au>Pangan, Aileen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinal Inflammation in the Absence of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in Patients With Active Nonradiographic Axial Spondyloarthritis</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheumatol</addtitle><date>2014-03</date><risdate>2014</risdate><volume>66</volume><issue>3</issue><spage>667</spage><epage>673</epage><pages>667-673</pages><issn>2326-5191</issn><eissn>2326-5205</eissn><abstract>Objective
To evaluate the presence of spinal inflammation with and without sacroiliac (SI) joint inflammation on magnetic resonance imaging (MRI) in patients with active nonradiographic axial spondyloarthritis (SpA), and to compare the disease characteristics of these subgroups.
Methods
ABILITY‐1 is a multicenter, randomized, controlled trial of adalimumab versus placebo in patients with nonradiographic axial SpA classified using the Assessment of SpondyloArthritis international Society axial SpA criteria. Baseline MRIs were centrally scored independently by 2 readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) method for the SI joints and the SPARCC 6–discovertebral unit method for the spine. Positive evidence of inflammation on MRI was defined as a SPARCC score of ≥2 for either the SI joints or the spine.
Results
Among patients with baseline SPARCC scores, 40% had an SI joint score of ≥2 and 52% had a spine score of ≥2. Forty‐nine percent of patients with baseline SI joint scores of <2, and 58% of those with baseline SI joint scores of ≥2, had a spine score of ≥2. Comparison of baseline disease characteristics by baseline SI joint and spine scores showed that a greater proportion of patients in the subgroup with a baseline SPARCC score of ≥2 for both SI joints and spine were male, and patients with spine and SI joint scores of <2 were younger and had shorter symptom duration. SPARCC spine scores correlated with baseline symptom duration, and SI joint scores correlated negatively with the baseline Bath Ankylosing Spondylitis Disease Activity Index, but neither correlated with the baseline Ankylosing Spondylitis Disease Activity Score, total back pain, the patient's global assessment of disease activity, the Bath Ankylosing Spondylitis Functional Index, morning stiffness, nocturnal pain, or C‐reactive protein level.
Conclusion
Assessment by experienced readers showed that spinal inflammation on MRI might be observed in half of patients with nonradiographic axial SpA without SI joint inflammation.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24574227</pmid><doi>10.1002/art.38283</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2014-03, Vol.66 (3), p.667-673 |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Adalimumab Adult Aged Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - therapeutic use Female Humans Inflammation Inflammation - complications Inflammation - pathology Male Middle Aged NMR Nuclear magnetic resonance Sacroiliitis - complications Sacroiliitis - pathology Severity of Illness Index Spine - pathology Spondylarthritis - complications Spondylarthritis - drug therapy Spondylarthritis - pathology Spondyloarthritis Treatment Outcome |
| title | Spinal Inflammation in the Absence of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in Patients With Active Nonradiographic Axial Spondyloarthritis |
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