Significance of viral status on occurrence of hepatitis B-related hepatocellular carcinoma
Hepatitis B virus(HBV)infection remains a challenging global health problem,with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma(HCC).Interactions that occur among host,environmental,and viral factors determine the natural course and predict the p...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-05, Vol.20 (20), p.5999-6005 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Qu, Li-Shuai Zhou, Guo-Xiong |
| description | Hepatitis B virus(HBV)infection remains a challenging global health problem,with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma(HCC).Interactions that occur among host,environmental,and viral factors determine the natural course and predict the prognosis of patients with chronic HBV infection.In the past decades,several important viral factors of predictive of HCC have been identified,such as high hepatitis B surface antigen level,seropositivity of hepatitis B e antigen,high viral load,viral genotype,and specific viral sequence mutations.Identification of certain viral risk factors for HCC development and stratification of patient risk are very important to perform future surveillance programs.In this article,we thus reviewed the risk of viral factors involved in hepatocarcinogenesis. |
| doi_str_mv | 10.3748/wjg.v20.i20.5999 |
| format | Article |
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Zhou, Guo-Xiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-2ac9b97c5f606c54e468d2630a3f68d5bdb82dfc7f4407ddda38311f02706b293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>carcinoma</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>DNA, Viral - blood</topic><topic>Genotype</topic><topic>Hepatitis</topic><topic>Hepatitis B e Antigens - genetics</topic><topic>Hepatitis B Surface Antigens - genetics</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Hepatocellular</topic><topic>Humans</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - virology</topic><topic>Mutatio</topic><topic>Mutation</topic><topic>Risk Factors</topic><topic>Topic Highlight</topic><topic>Viral Load</topic><topic>virus</topic><toplevel>online_resources</toplevel><creatorcontrib>Qu, Li-Shuai</creatorcontrib><creatorcontrib>Zhou, Guo-Xiong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qu, Li-Shuai</au><au>Zhou, Guo-Xiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of viral status on occurrence of hepatitis B-related hepatocellular carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-05-28</date><risdate>2014</risdate><volume>20</volume><issue>20</issue><spage>5999</spage><epage>6005</epage><pages>5999-6005</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Hepatitis B virus(HBV)infection remains a challenging global health problem,with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma(HCC).Interactions that occur among host,environmental,and viral factors determine the natural course and predict the prognosis of patients with chronic HBV infection.In the past decades,several important viral factors of predictive of HCC have been identified,such as high hepatitis B surface antigen level,seropositivity of hepatitis B e antigen,high viral load,viral genotype,and specific viral sequence mutations.Identification of certain viral risk factors for HCC development and stratification of patient risk are very important to perform future surveillance programs.In this article,we thus reviewed the risk of viral factors involved in hepatocarcinogenesis.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>24876722</pmid><doi>10.3748/wjg.v20.i20.5999</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2014-05, Vol.20 (20), p.5999-6005 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | carcinoma Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - virology DNA, Viral - blood Genotype Hepatitis Hepatitis B e Antigens - genetics Hepatitis B Surface Antigens - genetics Hepatitis B virus Hepatitis B, Chronic - complications Hepatitis B, Chronic - virology Hepatocellular Humans Liver Neoplasms - epidemiology Liver Neoplasms - virology Mutatio Mutation Risk Factors Topic Highlight Viral Load virus |
| title | Significance of viral status on occurrence of hepatitis B-related hepatocellular carcinoma |
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