Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

DNA lesions that block replication fork progression are drivers of cancer-associated genome alterations, but the error-prone DNA repair mechanisms acting on collapsed replication are incompletely understood, and their contribution to genome evolution largely unexplored. Here, through whole-genome se...

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Veröffentlicht in:	Genome research 2014-06, Vol.24 (6), p.954-962
Hauptverfasser:	Roerink, Sophie F, van Schendel, Robin, Tijsterman, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Polymerase theta DNA Replication DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Genome, Helminth Genomic Structural Variation
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