Contrasting Alterations to Synaptic and Intrinsic Properties in Upper-Cervical Superficial Dorsal Horn Neurons following Acute Neck Muscle Inflammation

Background: Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal models of axial pain are not widely available. Acc...

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Veröffentlicht in:	Molecular pain 2014-04, Vol.10 (1), p.25-25
Hauptverfasser:	Harris, Belinda M, Hughes, David I, Bolton, Philip S, Tadros, Melissa A, Callister, Robert J, Graham, Brett A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analysis of Variance Animal experimentation Animal models Animals Brain slice preparation c-Fos protein Care and treatment Carrageenan - toxicity Carrageenans Carrageenin Chronic pain Complications and side effects Diagnosis Disease Models, Animal Dorsal horn Electric Stimulation Excitatory postsynaptic potentials Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Functional Laterality - drug effects Functional Laterality - physiology Ganglia, Spinal - pathology Health aspects In Vitro Techniques Inflammation Labeling Male Membrane potential Mice Mice, Inbred C57BL Myositis - chemically induced Myositis - complications Neck Muscles - pathology Neurons Neurophysiology Neuroprotection Neurosciences Patch-Clamp Techniques Patient outcomes Physiological aspects Proto-Oncogene Proteins c-fos - metabolism Risk factors Rodents Sensory Receptor Cells - physiology Spinal cord Studies Synapses - drug effects Synapses - physiology
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