DNA degradation and its defects

DNA degradation and its defects

DNA is one of the most essential molecules in organisms, containing all the information necessary for organisms to live. It replicates and provides a mechanism for heredity and evolution. Various events cause the degradation of DNA into nucleotides. DNA also has a darker side that has only recently...

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Veröffentlicht in:Cold Spring Harbor perspectives in biology 2014-06, Vol.6 (6), p.a016394-a016394
Hauptverfasser: Kawane, Kohki, Motani, Kou, Nagata, Shigekazu
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Nucleus - metabolism
Cytosol - metabolism
DNA - metabolism
Gene Expression
Humans
Hydrolysis
PERSPECTIVES
Signal Transduction
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creator Kawane, Kohki
Motani, Kou
Nagata, Shigekazu
description DNA is one of the most essential molecules in organisms, containing all the information necessary for organisms to live. It replicates and provides a mechanism for heredity and evolution. Various events cause the degradation of DNA into nucleotides. DNA also has a darker side that has only recently been recognized; DNA that is not properly degraded causes various diseases. In this review, we discuss four deoxyribonucleases that function in the nucleus, cytosol, and lysosomes, and how undigested DNA causes such diseases as cancer, cataract, and autoinflammation. Studies on the biochemical and physiological functions of deoxyribonucleases should continue to increase our understanding of cellular functions and human diseases.
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subjects Animals
Cell Nucleus - metabolism
Cytosol - metabolism
DNA - metabolism
Gene Expression
Humans
Hydrolysis
PERSPECTIVES
Signal Transduction
title DNA degradation and its defects
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