Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system
The BDNF is required for the development and proper function of the central nervous system, where it is involved in a variety of neural and molecular events relevant to cognition, learning, and memory processes. Although only a functional mature protein is synthesized, the human BDNF gene possesses...
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| Veröffentlicht in: | The Yale journal of biology & medicine 2014-06, Vol.87 (2), p.173-186 |
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| creator | Martínez-Levy, Gabriela A Cruz-Fuentes, Carlos S |
| description | The BDNF is required for the development and proper function of the central nervous system, where it is involved in a variety of neural and molecular events relevant to cognition, learning, and memory processes. Although only a functional mature protein is synthesized, the human BDNF gene possesses an extensive structural complexity, including the presence of multiple promoters, splicing events, and 3´UTR poly-adenylation sites, resulting in an intricate transcriptional regulation and numerous messengers RNA. Recent data support specific cellular roles of these transcripts. Moreover, a central role of epigenetic modifications on the regulation of BDNF gene transcription is also emerging. The present essay aims to summarize the published information on the matter, emphasizing their possible implications in health and disease or in the treatment of different neurologic and psychiatric disorders. |
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Although only a functional mature protein is synthesized, the human BDNF gene possesses an extensive structural complexity, including the presence of multiple promoters, splicing events, and 3´UTR poly-adenylation sites, resulting in an intricate transcriptional regulation and numerous messengers RNA. Recent data support specific cellular roles of these transcripts. Moreover, a central role of epigenetic modifications on the regulation of BDNF gene transcription is also emerging. 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The present essay aims to summarize the published information on the matter, emphasizing their possible implications in health and disease or in the treatment of different neurologic and psychiatric disorders.</description><subject>3' Untranslated regions</subject><subject>Adenylation</subject><subject>Alzheimer's disease</subject><subject>Antidepressants</subject><subject>Binding sites</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Central nervous system</subject><subject>Central Nervous System - metabolism</subject><subject>Cognition</subject><subject>DNA methylation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Humans</subject><subject>Mental disorders</subject><subject>Nervous system</subject><subject>Neuroblastoma</subject><subject>Neurogenesis</subject><subject>Protein Isoforms - genetics</subject><subject>Protein Isoforms - metabolism</subject><subject>Protein Processing, Post-Translational</subject><subject>Proteins</subject><subject>Review</subject><subject>Transcription factors</subject><subject>Transcription, Genetic</subject><issn>0044-0086</issn><issn>1551-4056</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9Lw0AQxYMotla_gix48RLY_0kughStQsGLnsMmmTRb0t24uyn027vUKOrJ0zDMjzfvzZwkcyIESTkW8jSZY8x5inEuZ8mF91uMmSCCnSczygsSETZPuhUYCLpGyjQIBr2ZWgebsVdBW4Nsi0IHqHJKm7QBp_fQIAOjs8HZoYtwq-pgHdLmCNZgglN9RNzejh75gw-wu0zOWtV7uJrqInl7fHhdPqXrl9Xz8n6dDpTTkAqpsJKyoFzWGROKS1W0kmOWZy1UmZCENk0FGVVVU4PAVRuD1DktqFQ0DtgiufvUHcZqB81kphyc3il3KK3S5e-J0V25sfsy7iBZQaLA7STg7PsIPpQ77Wvoe2UgximJ4JKSXOTiPyjHmBSsiOjNH3RrR2fiJUqaUcE4p0fq-qf5b9df_2IfviyUGw</recordid><startdate>20140606</startdate><enddate>20140606</enddate><creator>Martínez-Levy, Gabriela A</creator><creator>Cruz-Fuentes, Carlos S</creator><general>Yale Journal of Biology and Medicine</general><general>YJBM</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140606</creationdate><title>Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system</title><author>Martínez-Levy, Gabriela A ; 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| subjects | 3' Untranslated regions Adenylation Alzheimer's disease Antidepressants Binding sites Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Central nervous system Central Nervous System - metabolism Cognition DNA methylation Epigenesis, Genetic Epigenetics Gene expression Gene regulation Humans Mental disorders Nervous system Neuroblastoma Neurogenesis Protein Isoforms - genetics Protein Isoforms - metabolism Protein Processing, Post-Translational Proteins Review Transcription factors Transcription, Genetic |
| title | Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system |
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