Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area
Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2009-10, Vol.326 (5951), p.445-449 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 449 |
|---|---|
| container_issue | 5951 |
| container_start_page | 445 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 326 |
| creator | Sahin, Ned T Pinker, Steven Cash, Sydney S Schomer, Donald Halgren, Eric |
| description | Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local field potentials from populations of neurons using electrodes implanted in language-related brain regions while people read words verbatim or grammatically inflected them (present/past or singular/plural). Neighboring probes within Broca's area revealed distinct neuronal activity for lexical (approximately 200 milliseconds), grammatical (approximately 320 milliseconds), and phonological (approximately 450 milliseconds) processing, identically for nouns and verbs, in a region activated in the same patients and task in functional magnetic resonance imaging. This suggests that a linguistic processing sequence predicted on computational grounds is implemented in the brain in fine-grained spatiotemporally patterned activity. |
| doi_str_mv | 10.1126/science.1174481 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4030760</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40328705</jstor_id><sourcerecordid>40328705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c683t-c582ebc2b0ba3af9d7e61803a00f16a0f7d400323c5772a49493bfe219b849ee3</originalsourceid><addsrcrecordid>eNqNks9rFDEcxYModrt69qQOgnpx7DfJTDK5CLVoLSxYqMVj-E42s5tlJmmT2aL_vVl2WH9c6ikk75MXvi-PkGcU3lPKxEkyznpj80ZWVUMfkBkFVZeKAX9IZgBclA3I-ogcp7QByJrij8kRVQ3nStIZ0Vf2dmv96LAvLmMwNiXnV0XoioX94Qz274rziMOA436DfllcroMPfVjtTooL34W4k4Mvvrtx7XzxMfvg21ScRotPyKMO-2SfTuucXH_-9O3sS7n4en5xdroojWj4WJq6YbY1rIUWOXZqKa2gDXAE6KhA6OSyytMwbmopGVaqUrztLKOqbSplLZ-TD3vfm2072KXJI0Xs9U10A8afOqDTfyverfUq3OkKOEgB2eDNZBBDTiSNenDJ2L5Hb8M2aSGFAqnovSAXrKIS-L0go1TVnML_gKB4tXv61T_gJmyjz7lmhteqAZAZOtlDJoaUou0OIVDQu9LoqTR6Kk2-8eLP7H7zU0sy8HoCMOU_7yJ649KBYwxqLsRu4ud7bpPGEA96jpg1MjNz8nKvdxg0rmL2uL5iQDlQkSvLGv4Lserd3A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213598007</pqid></control><display><type>article</type><title>Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area</title><source>MEDLINE</source><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><creator>Sahin, Ned T ; Pinker, Steven ; Cash, Sydney S ; Schomer, Donald ; Halgren, Eric</creator><creatorcontrib>Sahin, Ned T ; Pinker, Steven ; Cash, Sydney S ; Schomer, Donald ; Halgren, Eric</creatorcontrib><description>Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local field potentials from populations of neurons using electrodes implanted in language-related brain regions while people read words verbatim or grammatically inflected them (present/past or singular/plural). Neighboring probes within Broca's area revealed distinct neuronal activity for lexical (approximately 200 milliseconds), grammatical (approximately 320 milliseconds), and phonological (approximately 450 milliseconds) processing, identically for nouns and verbs, in a region activated in the same patients and task in functional magnetic resonance imaging. This suggests that a linguistic processing sequence predicted on computational grounds is implemented in the brain in fine-grained spatiotemporally patterned activity.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1174481</identifier><identifier>PMID: 19833971</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Adult ; Biological and medical sciences ; Brain Mapping ; Brocas area ; Cognition & reasoning ; Electrodes, Implanted ; Electrophysiological Phenomena ; Epilepsy - physiopathology ; Female ; Frontal Lobe - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Language ; Linguistic inflection ; Linguistics ; Magnetic Resonance Imaging ; Mental Processes - physiology ; Middle Aged ; Neurology ; Neurons ; Neurons - physiology ; Nouns ; Phonetics ; Phonology ; Speech - physiology ; Substrates ; Temporal lobe ; Time Factors ; Verbs ; Vertebrates: nervous system and sense organs ; Words</subject><ispartof>Science (American Association for the Advancement of Science), 2009-10, Vol.326 (5951), p.445-449</ispartof><rights>Copyright 2009 General Electric Company</rights><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c683t-c582ebc2b0ba3af9d7e61803a00f16a0f7d400323c5772a49493bfe219b849ee3</citedby><cites>FETCH-LOGICAL-c683t-c582ebc2b0ba3af9d7e61803a00f16a0f7d400323c5772a49493bfe219b849ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40328705$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40328705$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22053663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19833971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Ned T</creatorcontrib><creatorcontrib>Pinker, Steven</creatorcontrib><creatorcontrib>Cash, Sydney S</creatorcontrib><creatorcontrib>Schomer, Donald</creatorcontrib><creatorcontrib>Halgren, Eric</creatorcontrib><title>Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local field potentials from populations of neurons using electrodes implanted in language-related brain regions while people read words verbatim or grammatically inflected them (present/past or singular/plural). Neighboring probes within Broca's area revealed distinct neuronal activity for lexical (approximately 200 milliseconds), grammatical (approximately 320 milliseconds), and phonological (approximately 450 milliseconds) processing, identically for nouns and verbs, in a region activated in the same patients and task in functional magnetic resonance imaging. This suggests that a linguistic processing sequence predicted on computational grounds is implemented in the brain in fine-grained spatiotemporally patterned activity.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Brocas area</subject><subject>Cognition & reasoning</subject><subject>Electrodes, Implanted</subject><subject>Electrophysiological Phenomena</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>Frontal Lobe - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Language</subject><subject>Linguistic inflection</subject><subject>Linguistics</subject><subject>Magnetic Resonance Imaging</subject><subject>Mental Processes - physiology</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Nouns</subject><subject>Phonetics</subject><subject>Phonology</subject><subject>Speech - physiology</subject><subject>Substrates</subject><subject>Temporal lobe</subject><subject>Time Factors</subject><subject>Verbs</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Words</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9rFDEcxYModrt69qQOgnpx7DfJTDK5CLVoLSxYqMVj-E42s5tlJmmT2aL_vVl2WH9c6ikk75MXvi-PkGcU3lPKxEkyznpj80ZWVUMfkBkFVZeKAX9IZgBclA3I-ogcp7QByJrij8kRVQ3nStIZ0Vf2dmv96LAvLmMwNiXnV0XoioX94Qz274rziMOA436DfllcroMPfVjtTooL34W4k4Mvvrtx7XzxMfvg21ScRotPyKMO-2SfTuucXH_-9O3sS7n4en5xdroojWj4WJq6YbY1rIUWOXZqKa2gDXAE6KhA6OSyytMwbmopGVaqUrztLKOqbSplLZ-TD3vfm2072KXJI0Xs9U10A8afOqDTfyverfUq3OkKOEgB2eDNZBBDTiSNenDJ2L5Hb8M2aSGFAqnovSAXrKIS-L0go1TVnML_gKB4tXv61T_gJmyjz7lmhteqAZAZOtlDJoaUou0OIVDQu9LoqTR6Kk2-8eLP7H7zU0sy8HoCMOU_7yJ649KBYwxqLsRu4ud7bpPGEA96jpg1MjNz8nKvdxg0rmL2uL5iQDlQkSvLGv4Lserd3A</recordid><startdate>20091016</startdate><enddate>20091016</enddate><creator>Sahin, Ned T</creator><creator>Pinker, Steven</creator><creator>Cash, Sydney S</creator><creator>Schomer, Donald</creator><creator>Halgren, Eric</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091016</creationdate><title>Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area</title><author>Sahin, Ned T ; Pinker, Steven ; Cash, Sydney S ; Schomer, Donald ; Halgren, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c683t-c582ebc2b0ba3af9d7e61803a00f16a0f7d400323c5772a49493bfe219b849ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Brocas area</topic><topic>Cognition & reasoning</topic><topic>Electrodes, Implanted</topic><topic>Electrophysiological Phenomena</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>Frontal Lobe - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Language</topic><topic>Linguistic inflection</topic><topic>Linguistics</topic><topic>Magnetic Resonance Imaging</topic><topic>Mental Processes - physiology</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Nouns</topic><topic>Phonetics</topic><topic>Phonology</topic><topic>Speech - physiology</topic><topic>Substrates</topic><topic>Temporal lobe</topic><topic>Time Factors</topic><topic>Verbs</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Words</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Ned T</creatorcontrib><creatorcontrib>Pinker, Steven</creatorcontrib><creatorcontrib>Cash, Sydney S</creatorcontrib><creatorcontrib>Schomer, Donald</creatorcontrib><creatorcontrib>Halgren, Eric</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Ned T</au><au>Pinker, Steven</au><au>Cash, Sydney S</au><au>Schomer, Donald</au><au>Halgren, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2009-10-16</date><risdate>2009</risdate><volume>326</volume><issue>5951</issue><spage>445</spage><epage>449</epage><pages>445-449</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local field potentials from populations of neurons using electrodes implanted in language-related brain regions while people read words verbatim or grammatically inflected them (present/past or singular/plural). Neighboring probes within Broca's area revealed distinct neuronal activity for lexical (approximately 200 milliseconds), grammatical (approximately 320 milliseconds), and phonological (approximately 450 milliseconds) processing, identically for nouns and verbs, in a region activated in the same patients and task in functional magnetic resonance imaging. This suggests that a linguistic processing sequence predicted on computational grounds is implemented in the brain in fine-grained spatiotemporally patterned activity.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>19833971</pmid><doi>10.1126/science.1174481</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2009-10, Vol.326 (5951), p.445-449 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4030760 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Adult Biological and medical sciences Brain Mapping Brocas area Cognition & reasoning Electrodes, Implanted Electrophysiological Phenomena Epilepsy - physiopathology Female Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology Humans Language Linguistic inflection Linguistics Magnetic Resonance Imaging Mental Processes - physiology Middle Aged Neurology Neurons Neurons - physiology Nouns Phonetics Phonology Speech - physiology Substrates Temporal lobe Time Factors Verbs Vertebrates: nervous system and sense organs Words |
| title | Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T16%3A33%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sequential%20Processing%20of%20Lexical,%20Grammatical,%20and%20Phonological%20Information%20Within%20Broca's%20Area&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Sahin,%20Ned%20T&rft.date=2009-10-16&rft.volume=326&rft.issue=5951&rft.spage=445&rft.epage=449&rft.pages=445-449&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1174481&rft_dat=%3Cjstor_pubme%3E40328705%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213598007&rft_id=info:pmid/19833971&rft_jstor_id=40328705&rfr_iscdi=true |