Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study
Background Metabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on...
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| Veröffentlicht in: | Journal of diabetes and metabolic disorders 2014-04, Vol.13 (1), p.48-48, Article 48 |
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| creator | Halalkhor, Sohrab Jalali, Farzad Tilaki, Karimollah Hajian Shojaei, Shahla |
| description | Background
Metabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.
Methods
199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.
Results
We found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.
Conclusion
Our study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively. |
| doi_str_mv | 10.1186/2251-6581-13-48 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4030732</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541258947</galeid><sourcerecordid>A541258947</sourcerecordid><originalsourceid>FETCH-LOGICAL-b591t-fd1ce13585aba176a3501f5cc323d24918fd960c6956588d4f56e696da6ce9a03</originalsourceid><addsrcrecordid>eNp1ksFu1DAQhiMEotXSMzdkCQlxIK2dxI5zQVqqApUquMDZ8jqTXVeJJ9gO1T4LL1unW1a7Uusc7Mz_-bc9M1n2ltFzxqS4KArOcsEly1mZV_JFdrqPvDxYn2RnIdzSNOpaSiZeZydFVVMpKnma_VuGgMbqaNER7Ei8Q2JwGNLfiP12QD9ubBjCrOkUsSOOHiNYR5acrMEBubNxQwaIepVkQ8LWtR4HINa11uiIPqQl0eQH-gRee-2snt3HqX849lPSjMcQ8gBmDuiehDi12zfZq073Ac4e50X2--vVr8vv-c3Pb9eXy5t8xRsW865lBljJJdcrzWqhS05Zx40pi7ItqobJrm0ENaLhKR2yrTouQDSi1cJAo2m5yD7vfMdpNUBrwEWvezV6O2i_VaitOlac3ag1_lUVLWmdTllkX3YGK4vPGBwrKcNqro-a66NYqSqZTD4-3sLjnwlCVIMNBvpeO8ApKMZ5yWhVN_OF3-_Qte5BWddhcjUzrpa8YgWXTVUn6vwJKn0tDNagg86m-NGGDwcbNqD7uAnYT3NNwjF4sQMfyuah2z-VUTW35hOPe3eY4j3_vxETQHdASJJbg1e3OPnUCuFZz3uE1_Bq</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1553104790</pqid></control><display><type>article</type><title>Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study</title><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Halalkhor, Sohrab ; Jalali, Farzad ; Tilaki, Karimollah Hajian ; Shojaei, Shahla</creator><creatorcontrib>Halalkhor, Sohrab ; Jalali, Farzad ; Tilaki, Karimollah Hajian ; Shojaei, Shahla</creatorcontrib><description>Background
Metabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.
Methods
199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.
Results
We found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.
Conclusion
Our study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively.</description><identifier>ISSN: 2251-6581</identifier><identifier>EISSN: 2251-6581</identifier><identifier>DOI: 10.1186/2251-6581-13-48</identifier><identifier>PMID: 24708648</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Apolipoproteins ; Diabetes ; Endocrinology ; Genetic aspects ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Research Article ; Triglycerides</subject><ispartof>Journal of diabetes and metabolic disorders, 2014-04, Vol.13 (1), p.48-48, Article 48</ispartof><rights>Halalkhor et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated.</rights><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>Copyright © 2014 Halalkhor et al.; licensee BioMed Central Ltd. 2014 Halalkhor et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b591t-fd1ce13585aba176a3501f5cc323d24918fd960c6956588d4f56e696da6ce9a03</citedby><cites>FETCH-LOGICAL-b591t-fd1ce13585aba176a3501f5cc323d24918fd960c6956588d4f56e696da6ce9a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030732/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030732/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24708648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halalkhor, Sohrab</creatorcontrib><creatorcontrib>Jalali, Farzad</creatorcontrib><creatorcontrib>Tilaki, Karimollah Hajian</creatorcontrib><creatorcontrib>Shojaei, Shahla</creatorcontrib><title>Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study</title><title>Journal of diabetes and metabolic disorders</title><addtitle>J Diabetes Metab Disord</addtitle><addtitle>J Diabetes Metab Disord</addtitle><description>Background
Metabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.
Methods
199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.
Results
We found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.
Conclusion
Our study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively.</description><subject>Apolipoproteins</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Genetic aspects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Research Article</subject><subject>Triglycerides</subject><issn>2251-6581</issn><issn>2251-6581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp1ksFu1DAQhiMEotXSMzdkCQlxIK2dxI5zQVqqApUquMDZ8jqTXVeJJ9gO1T4LL1unW1a7Uusc7Mz_-bc9M1n2ltFzxqS4KArOcsEly1mZV_JFdrqPvDxYn2RnIdzSNOpaSiZeZydFVVMpKnma_VuGgMbqaNER7Ei8Q2JwGNLfiP12QD9ubBjCrOkUsSOOHiNYR5acrMEBubNxQwaIepVkQ8LWtR4HINa11uiIPqQl0eQH-gRee-2snt3HqX849lPSjMcQ8gBmDuiehDi12zfZq073Ac4e50X2--vVr8vv-c3Pb9eXy5t8xRsW865lBljJJdcrzWqhS05Zx40pi7ItqobJrm0ENaLhKR2yrTouQDSi1cJAo2m5yD7vfMdpNUBrwEWvezV6O2i_VaitOlac3ag1_lUVLWmdTllkX3YGK4vPGBwrKcNqro-a66NYqSqZTD4-3sLjnwlCVIMNBvpeO8ApKMZ5yWhVN_OF3-_Qte5BWddhcjUzrpa8YgWXTVUn6vwJKn0tDNagg86m-NGGDwcbNqD7uAnYT3NNwjF4sQMfyuah2z-VUTW35hOPe3eY4j3_vxETQHdASJJbg1e3OPnUCuFZz3uE1_Bq</recordid><startdate>20140407</startdate><enddate>20140407</enddate><creator>Halalkhor, Sohrab</creator><creator>Jalali, Farzad</creator><creator>Tilaki, Karimollah Hajian</creator><creator>Shojaei, Shahla</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140407</creationdate><title>Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study</title><author>Halalkhor, Sohrab ; Jalali, Farzad ; Tilaki, Karimollah Hajian ; Shojaei, Shahla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b591t-fd1ce13585aba176a3501f5cc323d24918fd960c6956588d4f56e696da6ce9a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Apolipoproteins</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Genetic aspects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Research Article</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halalkhor, Sohrab</creatorcontrib><creatorcontrib>Jalali, Farzad</creatorcontrib><creatorcontrib>Tilaki, Karimollah Hajian</creatorcontrib><creatorcontrib>Shojaei, Shahla</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes and metabolic disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halalkhor, Sohrab</au><au>Jalali, Farzad</au><au>Tilaki, Karimollah Hajian</au><au>Shojaei, Shahla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study</atitle><jtitle>Journal of diabetes and metabolic disorders</jtitle><stitle>J Diabetes Metab Disord</stitle><addtitle>J Diabetes Metab Disord</addtitle><date>2014-04-07</date><risdate>2014</risdate><volume>13</volume><issue>1</issue><spage>48</spage><epage>48</epage><pages>48-48</pages><artnum>48</artnum><issn>2251-6581</issn><eissn>2251-6581</eissn><abstract>Background
Metabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.
Methods
199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.
Results
We found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.
Conclusion
Our study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively.</abstract><cop>London</cop><pub>BioMed Central</pub><pmid>24708648</pmid><doi>10.1186/2251-6581-13-48</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Apolipoproteins Diabetes Endocrinology Genetic aspects Medicine Medicine & Public Health Metabolic Diseases Research Article Triglycerides |
| title | Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study |
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