Cytomegalovirus miRNAs Target Secretory Pathway Genes to Facilitate Formation of the Virion Assembly Compartment and Reduce Cytokine Secretion

Herpesviruses, including human cytomegalovirus (HCMV), encode multiple microRNAs (miRNA) whose targets are just being uncovered. Moreover, miRNA function during the virus life cycle is relatively unknown. We find that HCMV miRs UL112-1, US5-1, and US5-2 target multiple components of the host secreto...

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Veröffentlicht in:	Cell host & microbe 2014-03, Vol.15 (3), p.363-373
Hauptverfasser:	Hook, Lauren M., Grey, Finn, Grabski, Robert, Tirabassi, Rebecca, Doyle, Tracy, Hancock, Meaghan, Landais, Igor, Jeng, Sophia, McWeeney, Shannon, Britt, William, Nelson, Jay A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines - antagonists & inhibitors Cytokines - metabolism Cytomegalovirus - genetics Cytomegalovirus - physiology Golgi Apparatus - physiology Golgi Apparatus - virology Host-Pathogen Interactions Humans MicroRNAs - genetics MicroRNAs - metabolism Secretory Pathway - genetics Virus Assembly
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