Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

Introduction of an aliphatic side chain to a key position of a novel piperidine-based HDM2 inhibitor scaffold resulted in significant potency gains, enabling further series progression.

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Veröffentlicht in:ACS medicinal chemistry letters 2014-05, Vol.5 (5), p.572-575
Hauptverfasser: Ma, Yao, Lahue, Brian R, Gibeau, Craig R, Shipps, Gerald W, Bogen, Stéphane L, Wang, Yaolin, Guo, Zhuyan, Guzi, Timothy J
Format: Artikel
Sprache:eng
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Letter
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Zusammenfassung:Introduction of an aliphatic side chain to a key position of a novel piperidine-based HDM2 inhibitor scaffold resulted in significant potency gains, enabling further series progression.
ISSN:1948-5875
1948-5875
DOI:10.1021/ml500019s