Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class of high-throughput screening (HTS)-derived tetrahydropyrido[4,3-d]pyrimidine amide TGR5 agonists is disclosed. We describe our effort to ide...

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Veröffentlicht in:	ACS medicinal chemistry letters 2013-01, Vol.4 (1), p.63-68
Hauptverfasser:	Piotrowski, David W, Futatsugi, Kentaro, Warmus, Joseph S, Orr, Suvi T. M, Freeman-Cook, Kevin D, Londregan, Allyn T, Wei, Liuqing, Jennings, Sandra M, Herr, Michael, Coffey, Steven B, Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y, Chin, Janice E, Hadcock, John R, Brenner, Martin B, Wolford, Angela C, Janssen, Ann M, Roush, Nicole S, Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S, Sharma, Raman, Flynn, Declan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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