Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache

Animal models are essential for studying the pathophysiology of headache disorders and as a screening tool for new therapies. Most animal models modify a normal animal in an attempt to mimic migraine symptoms. They require manipulation to activate the trigeminal nerve or dural nociceptors. At best,...

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Veröffentlicht in:	Headache 2012-10, Vol.52 (9), p.1336-1349
Hauptverfasser:	Oshinsky, Michael L., Sanghvi, Menka M., Maxwell, Christina R., Gonzalez, Dorian, Spangenberg, Rebecca J., Cooper, Marnie, Silberstein, Stephen D.
Format:	Artikel
Sprache:	eng
Schlagworte:	allodynia Analgesics - pharmacology animal model Animal models Animals Biological and medical sciences biomarkers Calcitonin chronic daily headache Disease Models, Animal Drug development Glycerol Headache Headache - drug therapy Headache - physiopathology headache trigger Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Headaches Humans Hyperalgesia - drug therapy Hyperalgesia - physiopathology Mating Medical research Medical sciences Migraine Nervous system (semeiology, syndromes) Neurology Nociceptors Pain Pain perception primary headache Rats Rats, Sprague-Dawley Rodents sumatriptan Trigeminal nerve Trigeminal Nerve - physiopathology Valproic acid Vascular diseases and vascular malformations of the nervous system
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